Table 7.

Local Adverse Effects in the Two Treatment Sides

Side Effect	Right Side (Conventional Tretinoin)	Left Side (Ethosomal RP)	p-value
Erythema, n (%)
No	0 (0)	7 (35)	< 0.001
Mild	3 (15)	12 (60)
Moderate	15 (75)	1 (5)
Severe	2 (10)	0 (0)
Peeling, n (%)
No	0 (0)	7 (35)	< 0.001
Mild	7 (35)	12 (60)
Moderate	11 (55)	1 (5)
Severe	2 (10)	0 (0)
Burning, n (%)
No	0 (0)	3 (15)	< 0.001
Mild	5 (25)	15 (75)
Moderate	11 (55)	2 (10)
Severe	4 (20)	0 (0)
Pruritus, n (%)
No	1 (5)	4 (20)	< 0.001
Mild	1 (5)	15 (75)
Moderate	12 (60)	1 (5)
Severe	6 (30)	0 (0)