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. 2021 Jun 15;11:685515. doi: 10.3389/fonc.2021.685515

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Copyright © 2021 Yi, Zhang, Ng, Xi, Ye, Cen, Li, Fan, Li, Hu, Rong, Xie, Zhao, Chen, Chen, Ni, Mi, Dai and Liao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationships between immune infiltration and DMPs regulated by TMGs in RCC. (A) The number and the proportions of positive and negative TMG-DMP relationships. (B) The GO functional enrichment analysis of the genes which are positively correlated with the DNA methylation level of TMG-upregulating DMPs. (C) No significant result was found in the genes which are positively correlated with the DNA methylation level of TMG-downregulating DMPs. (D) The GO functional enrichment analysis of the genes which are negatively correlated with the DNA methylation level of TMG-upregulating DMPs. (E) The GO functional enrichment analysis of the genes which are negatively correlated with the DNA methylation level of TMG-downregulating DMPs. (F) The network among TMGs (blue), DNA methylation probes (green) and genes (red) whose functions are annotated with T cell activation, of these, DNA methylation probes are derived from PDCD1 and PDCD1LG2.