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. 2021 Jun 15;11:685515. doi: 10.3389/fonc.2021.685515

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Copyright © 2021 Yi, Zhang, Ng, Xi, Ye, Cen, Li, Fan, Li, Hu, Rong, Xie, Zhao, Chen, Chen, Ni, Mi, Dai and Liao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagrams show the overlapping immune-related TMGs identified using the immune score-based method, gene expression-based method, miRNA target-based method, and DNA methylation-based method in RCC (A) and LCC (B). (C) Positive correlation network centered on immune-related TMGs in RCC. (D) Negative correlation network centered on immune-related TMGs in RCC. (E) Positive correlation network centered on immune-related TMGs in LCC. (F) Negative correlation network centered on immune-related TMGs in LCC. The color strength represents the fold change of expression in the high-immunity group compared to that in the low-immunity group. Red indicates up-regulation while blue suggests down-regulation in the high-immunity group. The nodes with a blue edge represent TMGs, the nodes with no edge represent DEGs, the nodes with a purple edge represent the genes regulated by TMG-regulating DMPs while those with green edges represent miRNAs.