Table 1.
Comparison of molecular subtypes and clinical characteristics between RCC and LCC (N =434).
| Characteristics | Category | RCC(N/%) | LCC(N/%) | T-test/χ 2 | P |
|---|---|---|---|---|---|
| Microsatellite | MSI-H# | 72(28.5) | 4(2.4) | 35.352a | <0.001* |
| MSI-L# | 39(15.4) | 34(20.7) | |||
| MSS# | 142(56.1) | 126(76.8) | |||
| Methylation | CIMP-H# | 94(54.7) | 4(4.0) | 70.388b | <0.001 |
| CIMP-L# | 78(45.3) | 96(96.0) | |||
| Chromosome | CIN# | 107(43.0) | 104(63.8) | 17.110b | <0.001* |
| Non-CIN# | 142(57.0) | 59(36.2) | |||
| Age | 68.51 ± 13.37 | 64.89 ± 12.48 | 2.848c | 0.005* | |
| Stage | I | 44(17.7) | 30(17.2) | 2.862a | 0.091 |
| II | 109(43.8) | 62(35.6) | |||
| III | 68(27.3) | 51(29.3) | |||
| IV | 28(11.2) | 31(17.8) | |||
| Gender | Man | 135(52.3) | 92(52.3) | 0b | 1 |
| Woman | 123(47.7) | 84(47.7) | |||
| Race | American Indian or Alaska Native | 0(0) | 1(1.0) | 4.725b | 0.193 |
| Asian | 8(4.7) | 3(3.2) | |||
| Black or African American | 41(24.3) | 15(16.0) | |||
| White | 120(71.0) | 75(79.8) | |||
| Intestinal polyp | Yes | 78(35.5) | 55(35.7) | 0.003b | 0.959 |
| No | 142(64.5) | 99(64.3) | |||
| Relapse | Yes | 42(19.9) | 34(23.6) | 0.699b | 0.403 |
| No | 169(80.1) | 110(76.4) | |||
| Lymphatic invasion | Yes | 83(35.9) | 70(43.5) | 2.271b | 0.132 |
| No | 148(64.1) | 91(56.5) | |||
| T | Tis# | 1(0.4) | 0(0) | 1.477a | 0.224 |
| T1# | 5(1.9) | 4(2.3) | |||
| T2# | 42(16.3) | 34(19.3) | |||
| T3# | 174(67.4) | 122(69.3) | |||
| T4# | 36(14.0) | 16(9.1) | |||
| Metastases | M0# | 194(87.4) | 130(80.7) | 3.159b | 0.075 |
| M1# | 28(12.6) | 31(19.3) | |||
| Node | N0# | 163(63.2) | 96(54.5) | 0.565a | 0.452 |
| N1# | 45(17.4) | 51(29.0) | |||
| N2# | 50(19.4) | 29(16.5) |
aMantel-Haenszel’s chi-squared test; bPearson’s chi-squared test; cT-test;
#MSI-H, Microsatellite instability-high; MSI-L, Microsatellite instability-low; MSS, Microsatellite stability;
CIMP-H, CpG island methylator phenotype-high; CIMP-L, CpG island methylator phenotype-low;
CIN, Chromosome instability; Non-CIN, Nonchromosomal instability;
Tis: In situ, non-invasive (confined to epithelium); T1: Small, minimally invasive within primary organ site; T2: Larger, more invasive within primary organ site; T3: Larger and/or invasive beyond margins of primary organ site; T4: Very large and/or very invasive, spread to adjacent organs;
M0: No distant metastases; M1: Distant metastases present;
N0: No lymph node involvement; N1: Regional lymph node involvement; N2: Extensive regional lymph node involvement;
*P<0.05.