FIGURE 3.

Osteoking up-regulated the expression of TGFβRII and pSmad2 in DMM-induced WT osteoarthritic mice. (A) immunohistochemical staining of Col2, MMP-13, and pSmad2 and TGFβRII in cartilage. Scale bar = 100 μm. (B–E) Quantification of the positive repression area of Col2 (mm²), Percentage of positive expression of pSmad2, TGFβRII, and MMP-13 (%). Gait analysis was performed by DigiGait imaging system. (F) Swing (s), (G) Stride length (cm), (H) Stance (s), (I) Paw area (cm²) of the right hind limb were chosen as the observation index. The Data are presented as means ± SD (n = 10). The exact p value is presented in the corresponding graph.