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. 2021 Jun 15;12:678810. doi: 10.3389/fphar.2021.678810

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Copyright © 2021 Ling, Zeng, Ge, Chen, Yuan, Xu, Shi, Xia, Hu, Jin, Wang and Tong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cartilage protection effect of Osteoking was lost in TGFβRII^Col2ER mice. (A) Alcian blue hematoxylin/orange G staining and Toluidine blue staining of the tight knee joint in TGFβRII^Col2ER mice. Red arrows indicate the area of cartilage erosion. Scale bar = 100 μm. Morphological quantitative analysis of (B) area of tibial cartilage (mm²) and (C) thickness of tibial cartilage (μm). (D) OARSI scoring of the sections analyzed by histomorphometry. (E) Representative 3D reconstruction of the right knee joint and subchondral bone. Quantitative analysis of the subchondral bone of right knee joints (F) BV/TV (%), (G) Tb.Th (mm) and (H) BMD (g/cm³) were chosen as the observation indexes. Data are presented as means ± SD (n = 10). The exact p value is presented in the corresponding graph.