Table 1.
Patient characteristics
| Ward (n = 336) | ICU (n = 93) | p value | Total (n = 429) | |
|---|---|---|---|---|
| Demographics | ||||
| Age (years); (median, IQR) | 64 (25) | 64 (18) | 0.959 | 64 (27) |
| Sex (male); (n, %) | 187 (56) | 58 (62) | 0.247 | 245 (57) |
| BMIa (kg/m2); (median, IQR) | 26 (6) | 26 (6) | 0.156 | 26 (6) |
| Symptoms at admission (n, %) | ||||
| Fever or history of fever | 189 (58) | 52 (56) | 0.923 | 241 (61) |
| Fever at day 1 of hospitalization | 221 (68) | 73 (79) | 0.029* | 294 (70) |
| Dyspnoea | 183 (56) | 61 (66) | 0.060 | 244 (58) |
| Cough | 187 (57) | 48 (52) | 0.395 | 235 (56) |
| Thoracic pain | 55 (17) | 17 (18) | 0.734 | 72 (17) |
| Laboratory findings (median, IQR; except for lymphopenia) | ||||
| White blood cell count (/mm3) | 7150 (4525) | 7750 (4850) | 0.045 | 6800 (4400) |
| Neutrophil count (/mm3) | 5335 (4081) | 5986 (5078) | 0.093 | 5113 (3796) |
| Lymphocyte count (/mm3) | 995 (602) | 963 (528) | 0.357 | 1015 (606) |
| Ferritin (mcg/L) | 661 (1055) | 806 (1200) | 0.020* | 608 (1016) |
| CRPb (mg/dL) | 88 (140) | 139 (150) | < 0.001* | 71 (128) |
| Lymphopenia (< 1000/mm3); (n, %) | 202 (50) | 41 (44) | 0.221 | 239 (49) |
| Comorbidities | ||||
| CCIc (median, IQR) | 1 (3) | 1 (3) | 0.402 | 1 (3) |
| Chronic pulmonary disease (n, %) | 39 (12) | 11 (12) | 0.984 | 50 (12) |
| Ischaemic/congestive heart disease (n, %) | 49 (15) | 14 (15) | 0.976 | 63 (15) |
| Diabetes mellitus (n, %) | 69 (21) | 28 (30) | 0.069 | 97 (23) |
| Immune suppression (n, %) | 46 (14) | 16 (17) | 0.394 | 62 (14) |
| qSOFA score (median, IQR) | 0 (3) | 1 (2) | 0.124 | 1 (3) |
| Mechanical ventilation need (n, %) | NAd | 33 (35) | – | 33 (8) |
| (SpO2/FiO2 × 100) at admission (median, IQR) | 357 (124) | 296 (171) | < 0.001* | 350 (146) |
| (SpO2/FiO2 × 100) mine (median, IQR) | 321 (123) | 148 (29) | < 0.001* | 291 (192) |
| Mortality (n, %) | 30 (9) | 34 (37) | < 0.001* | 64 (15) |
IQR interquartile range
aBMI body mass index
bCRP C-reactive protein. Laboratory findings were collected at day 0 or 1 of hospitalization on a COVID 19 ward or ICU ward. If not available on day 0 or 1, the first available ferritin levels were collected
cCCI Charlson comorbidity index
dNA
eSpO2/FiO2 × 100 min = the lowest value of the SpO2/FiO2 rate during the total stay on a COVID-19 ward or in the ICU
*p values < 0.05