Table 3.
The 14 single-nucleotide polymorphisms (SNPs) used as instrumental variables (IVs) of polycystic ovary syndrome.
| rsID | Nearest gene | Effect allele | β | se | p-value | Secondary phenotype* |
|---|---|---|---|---|---|---|
| rs2178575 | ERBB4 | A | 0.1663 | 0.0219 | 3.34E-14 | / |
| rs11031005 | FSHB | T | −0.1593 | 0.0223 | 8.66E-13 | Length of menstrual cycle Age at menopause Years since last cervical smear test Bilateral oophorectomy Irregular menstruation |
| rs804279 | NEIL2 | A | 0.1276 | 0.0184 | 3.76E-12 | / |
| rs11225154 | YAP1 | A | 0.1787 | 0.0272 | 5.44E-11 | / |
| rs9696009 | DENND1A | A | 0.202 | 0.0311 | 7.96E-11 | / |
| rs13164856 | IRF1-AS1 | T | 0.1235 | 0.0193 | 1.45E-10 | Sum eosinophil and basophil counts Eosinophil count Height Neutrophil percentage of granulocytes Platelet count Whole body water mass Sitting height |
| rs1784692 | ZBTB16 | T | 0.1438 | 0.0226 | 1.88E-10 | / |
| rs7563201 | THADA | A | −0.1081 | 0.0172 | 3.68E-10 | / |
| rs8043701 | CASC22 | A | −0.1273 | 0.0208 | 9.61E-10 | / |
| rs1795379 | LOC105369844 | T | −0.1174 | 0.0195 | 1.81E-09 | / |
| rs853854 | MAPRE1 | A | −0.0975 | 0.0163 | 2.36E-09 | / |
| rs10739076 | PLGRKT | A | 0.1097 | 0.0197 | 2.51E-08 | / |
| rs7864171 | C9orf3 | A | −0.0933 | 0.0168 | 2.95E-08 | Height Trunk fat-free mass |
| rs2271194 | ERBB3 | A | 0.0971 | 0.0166 | 4.57E-09 | Allergic disease Eosinophil count Asthma Whole body water mass Rheumatoid arthritis Years of educational attainment Body mass index |
*
Secondary phenotypes were detected by PhenoScanner (www.phenoscanner.medschl.cam.ac.uk), with filtration of p <5 × 10−8 and r2 > 0.8.
rsID, the ID of the single nucleotide polymorphism (SNP); β, the effect size of the SNP; se, the standard error of the effect size; chr, chromosome; posi, position.