Table 4.
The 15 single-nucleotide polymorphisms (SNPs) used as instrumental variables of obsessive compulsive disorder (OCD).
| rsID | Nearest gene | Effect allele | β | se | p-value | Secondary phenotype* |
|---|---|---|---|---|---|---|
| rs1030757 | GRID2 | A | 0.847639 | 0.0339 | 1.09E-06 | / |
| rs116347760 | MAGI3 | A | 1.87705 | 0.1335 | 2.39E-06 | / |
| rs117310268 | RP11-595B24.2 | T | 1.56627 | 0.0965 | 3.31E-06 | / |
| rs12504244 | NMU | C | 0.844593 | 0.0352 | 1.62E-06 | Myeloid white cell count |
| rs12568997 | RN7SL583P | A | 0.745798 | 0.058 | 4.23E-07 | / |
| rs13141765 | RP11-586D19.1 | T | 0.766209 | 0.0558 | 1.86E-06 | / |
| rs4733767 | CASC8 | A | 1.21349 | 0.039 | 7.10E-07 | / |
| rs55687617 | RP11-10F11.3 | A | 0.763227 | 0.0575 | 2.67E-06 | / |
| rs56343802 | AHCYP4 | A | 0.843834 | 0.0368 | 3.97E-06 | / |
| rs639560 | PLA2G4D | T | 0.659812 | 0.0879 | 2.23E-06 | / |
| rs72781967 | RP13-463N16.6 | T | 0.846538 | 0.0353 | 2.43E-06 | / |
| rs72783425 | MKL2 | A | 1.40453 | 0.0733 | 3.53E-06 | / |
| rs77885126 | RP11-325K19.1 | T | 0.547441 | 0.1312 | 4.38E-06 | / |
| rs909701 | LINC00207 | C | 0.856073 | 0.0337 | 4.05E-06 | / |
| rs9952159 | DLGAP1 | T | 1.19997 | 0.0396 | 4.21E-06 | / |
*
Secondary phenotypes were detected by PhenoScanner (www.phenoscanner.medschl.cam.ac.uk), with filtration of p < 5 × 10−8 and r2 > 0.8.
rsID, the ID of the single nucleotide polymorphism (SNP); β, the effect size of the SNP; se, the standard error of the effect size.