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. 2021 Jun 15;12:663449. doi: 10.3389/fgene.2021.663449

TABLE 3.

Associations for low-risk sleep behaviors with risk of terminated health span among 328,850 participants.

Sleep behaviors Total (N) Cases (N) Basic model* Fully adjusted model† PAR% (95% CI)

HR (95% CI)a HR (95% CI)a
Early chronotype 206,425 (62.77) 31,686 (15.35) 0.95 (0.94–0.97) 1.00 (0.98–1.01) −1.42 (−2.04 to −0.80)
Sleep 7–8 h/day 227,871 (69.29) 33,049 (14.50) 0.88 (0.87–0.90) 0.94 (0.92–0.95) 4.17 (3.62–4.72)
Never/rarely insomnia 83,012 (25.24) 11,510 (13.87) 0.92 (0.90–0.94) 0.94 (0.92–0.96) 8.39 (7.02–9.74)
No self-reported snoring 207,777 (63.18) 29,664 (14.28) 0.93 (0.91–0.95) 0.99 (0.97–1.01) 5.67 (5.04–6.30)
Rarely daytime sleepiness 321,158 (97.66) 48,208 (15.01) 0.77 (0.73–0.81) 0.83 (0.79–0.87) 0.82 (0.68–0.96)
All five factors (overall)b 24,548 (7.46) 3,147 (12.82) 0.89 (0.86–0.92) 0.96 (0.93–1.00) 15.30 (12.58–17.93)

*Basic model: adjusted for age, sex, and ethnicity. aCompared with all other participants not in this low-risk group. bAll low-risk factors were included simultaneously in the same model, and participants without all five low-risk behaviors were set as the reference Fully adjusted model: additionally adjusted for Townsend Deprivation Index, education, BMI, smoking status, alcohol consumption, physical activity, healthy diet, family history of diseases (cancer and CCVD), and medication (sleep-related drugs and aspirin/ibuprofen).