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. 2021 Jun 15;8:698437. doi: 10.3389/fmed.2021.698437

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Copyright © 2021 Zhang, Xu, Shi, Li, Wang, An and Su.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network plots of each outcome. The network of eligible studies for different outcomes. Different color of nodes represents different treatment. The node sizes correspond to the number of participants that investigated the treatments. The thickness of edges represents the number of trials. A lack of line indicates that there were no head-to-head trials between two treatments for this outcome. (A) MACE (major adverse cardiovascular events), (B) non-fatal MI (myocardial infarction), (C) non-fatal stroke, and (D) cardiovascular death.