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Observed phenotypic penetrance of C2cd3ex2/ex2 mutants on CD1 and C57BL/6J backgrounds.
| Phenotype | Outcrossed | Backcrossed | |||
| CD1 | C57BL/6J F4 | ||||
| (n = 10) | (n = 9) | ||||
| Exencephaly | 9 (90%) | 6 (67%) | |||
| Tight mesencephalic flexure | 3 (30%) | 3 (33%) | |||
| Abnormal heart looping | 3 (30%) | 5 (56%) | |||
| Twisted body axis | 9 (90%) | 7 (78%) | |||
| Pericardial edema | 3 (30%) | 4 (44%) | |||
