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. 2021 Jun 15;12:694344. doi: 10.3389/fimmu.2021.694344

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Copyright © 2021 Lv, Mu, Du, Yan and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CBLEB alleviates cyclophosphamide-induced gut metabolism disorder. (A) OPLS-DA plot illustrating clear separation of gut metabolic profiles of the CTX (n = 6) and HC (n = 9) groups. (B) VIP values of 10 metabolites with the highest contribution to the differences between the CTX and HC groups. (C) Levels of eight metabolites reduced in the CTX group compared with those in the HC group. (D) Levels of six metabolites that were increased in the CTX group compared with those in the HC group. (E) OPLS-DA plot illustrating that gut metabolic profiles of the CTX+CBLEB (n = 8) group were in distinguishable from those of the HC (n = 9) group. (*P < 0.05; **P < 0.01; ***P < 0.001).