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. 2021 Jun 15;12:694344. doi: 10.3389/fimmu.2021.694344

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Copyright © 2021 Lv, Mu, Du, Yan and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CBLEB alleviates cyclophosphamide-induced serum metabolism disorders. (A) OPLS-DA plot illustrating clear separation of serum metabolic profiles of the CTX (n = 6) and HC (n = 9) groups. (B) VIP values of nine metabolites with the highest contribution to the differences between the CTX and HC groups. (C) Metabolites depleted after cyclophosphamide treatment and changes in their levels after CBLEB treatment. (D) Metabolites enriched after cyclophosphamide treatment and changes in their levels after CBLEB treatment. (E) OPLS-DA plot illustrating clear separation of serum metabolic profiles of the CTX+CBLEB (n = 8) and HC groups (n = 9). (*P < 0.05; **P < 0.01; ***P < 0.001).