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. 2021 Jun 15;12:678570. doi: 10.3389/fimmu.2021.678570

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Copyright © 2021 Bullen, Galson, Hall, Villar, Moreels, Ledsgaard, Mattiuzzo, Bentley, Masters, Tang, Millett, Tongue, Brown, Diamantopoulos, Parthiban, Tebbutt, Leah, Chaitanya, Ergueta-Carballo, Pazeraitis, Surade, Ashiru, Crippa, Cowan, Bowler, Campbell, Lee, Carr, Matthews, Pfeffer, Hufton, Sawmynaden, Osbourn, McCafferty and Karatt-Vellatt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detailed characterization of SARS-CoV-2 antibodies. (A) Evaluating the cross reactivity of 155 SARS-CoV-2 antibodies to SARS-CoV-1 RBD and MERS CoV S1. CR3022, a previously published binding SARS-CoV-1 and SARS-CoV-2 cross reactive antibody was used as control. (B) Authentic SARS-CoV-2 neutralizing activity of a panel of 21 SARS-CoV-2 antibodies and control antibodies. (C) Comparing authentic SARS-CoV-2 neutralizing activity of 4 antibodies, in Fab and IgG format. Error bars indicate standard deviation. (D) Epitope binning of SARS-CoV-2 antibody panel using Octet BioLayer interferometry. The bins are labeled A to G. Antibodies in bold text denote capture molecules that exhibited unidirectionality.