Table 3A.
Convergent clusters identified in the current study which also had sequences map to them from the CoV-AbDab.
| Convergent cluster ID | Representative CDRH3 | V gene |
J gene |
Cluster size | Mean mutation | Convergence | Number of CoV-AbDab hits |
|---|---|---|---|---|---|---|---|
| 1 | AAPDCSSTSCYDAFDI | VH1-58 | J3 | 1680 | 1.7 | 9 | 8 mAbs |
| 2 | ARDLVAYGMDV | VH3-66 | J6 | 164 | 2 | 9 | 10 mAbs |
| 3 | ARDLMVYGMDV | VH3-53 | J6 | 1202 | 2.1 | 14 | 14 mAbs |
| 4 | ARDAMSYGMDV | VH3-53 | J6 | 71 | 0.9 | 4 | 2 mAbs |
| 5 | ASSLWLRGSFDY | VH3-7 | J4 | 45 | 1.1 | 3 | 1 mAbs |
| 6 | AGGPNLNNWFDP | VH5-51 | J5 | 72 | 1.6 | 3 | 1 mAbs |
| 7 | ARDLDVRGGMDV | VH3-66 | J6 | 43 | 1.9 | 3 | 2 mAbs |
Table 3A shows the properties of convergent antibody clusters identified from the current study, including the size of the cluster (i.e., unique antibodies found in each cluster, an indicator of clonal expansion), number of different patients each cluster was present in (convergence) and number of antibodies found in the CoV-AbDab database with the same cluster identity.