TABLE 2.
Physiological and renal parameters of treatment rats
| Control + vehicle | Control + DAPA | DM + vehicle | DM + DAPA | |
|---|---|---|---|---|
| N | 6 | 6 | 8 | 12 |
| Body weight (g) | 730.8 ± 52.4 | 713.7 ± 26.4 | 472.5 ± 32.6* | 439.3 ± 20.2* |
| HbA1c (%) | 4.53 ± 0.21 | 4.65 ± 0.17 | 12.94 ± 0.04* | 9.41 ± 0.62* , † |
| Systolic blood pressure (mmHg) | 109.7 ± 7.1 | 124.7 ± 5.1 | 98.9 ± 5.6 # | 95.9 ± 4.0 # |
| GFR (µl/min/g) | 4.32 ± 0.34 | 3.84 ± 0.29 | 7.54 ± 0.26* | 5.84 ± 0.62* , † |
| Urine volume (ml/24 h) | 33.3 ± 3.6 | 66.5 ± 2.8 | 199.4 ± 18.1* | 186.9 ± 11.6* |
| Urinary glucose (mol/24 h) | 0.013 ± 0.003 | 26.31 ± 3.3 | 91.37 ± 7.8* | 78.60 ± 6.6* |
Abbreviations: GFR, glomerular filtration rate; HbA1C, glycosylated hemoglobin.
*
p < 0.05 vs. Control + DAPA and Control + vehicle group.
†
p < 0.05 vs. DM + vehicle group.
#
p < 0.05 vs. Control + DAPA group (Tukey's test).