TABLE 3.
Arterial blood gas and cooximetry data from both experimental protocols
| FIO2 (%) | Treatment | pH | pCO2 (mmHg) | pO2 (mmHg) | HCO3 (mmol/L) | Hb (g/L) | sO2 (%) | Lac (mmol/L) | Glu (mmol/L) |
|---|---|---|---|---|---|---|---|---|---|
| Experimental protocol #1 | |||||||||
| 21 | Control Vehicle | 7.42 ± 0.03 | 34.6 ± 2.8 | 80.6 ± 8.6 | 22.8 ± 0.8 | 129 ± 7.1 | 90 ± 2.9 | 1.63 ± 0.50 | 12.3 ± 2.5 |
| Control DAPA | 7.42 ± 0.02 | 36.8 ± 1.3 | 80.2 ± 8.8 | 23.8 ± 0.8 | 130 ± 7.3 | 89 ± 3.0 | 1.08 ± 0.25 | 10.3 ± 2.2 $ | |
| 50 | Control Vehicle | 7.37 ± 0.02* | 38.1 ± 2.1 | 187.0 ± 22* | 22.3 ± 1.2 | 129 ± 8.9 | 97 ± 0.3 | 1.77 ± 0.59 | 10.7 ± 2.9 |
| Control DAPA | 7.37 ± 0.02* | 38.1 ± 5.0 | 202.0 ± 21* | 22.1 ± 1.5 | 125 ± 8.4 | 97 ± 0.4 | 0.98 ± 0.37 | 8.8 ± 1.1 $ | |
| 21 | Control Vehicle | 7.38 ± 0.02 | 33.0 ± 3.2 | 73.9 ± 17 | 20.4 ± 1.0 | 113 ± 9.0 | 83 ± 13 | 2.90 ± 1.94 | 10.3 ± 4.9 |
| Control DAPA | 7.41 ± 0.02 | 35.6 ± 3.0 | 87.9 ± 11 | 23.4 ± 1.1 | 128 ± 8.7 | 91 ± 2.5 | 1.90 ± 0.44 | 11.1 ± 1.0 $ | |
| 21 | DM Vehicle | 7.37 ± 0.04 $ , ǂ | 34.3 ± 6.6 | 87.7 ± 21 | 21.0 ± 3.1 | 138 ± 8.8 | 88 ± 2.3 | 1.52 ± 0.93 | 21.0 ± 8.2 |
| DM DAPA | 7.30 ± 0.09 $ , ǂ | 31.4 ± 5.5 | 86.5 ± 10 | 16.4 ± 3.9 | 122 ± 12 | 87 ± 3.5 | 1.69 ± 0.65 | 12.7 ± 2.9 | |
| 50 | DM Vehicle | 7.25 ± 0.10 $ , ǂ , * | 42.1 ± 11 | 197.7 ± 32* | 17.7 ± 4.3 $ , ǂ | 136 ± 4.2* | 96 ± 0.7* | 1.95 ± 1.15* | 21.8 ± 2.1 * |
| DM DAPA | 7.24 ± 0.09 $ , ǂ , * | 34.0 ± 5.7 | 213.2 ± 34* | 15.7 ± 4.4 # , $ , ǂ | 127 ± 11 # , * | 97 ± 0.6* | 1.54 ± 0.64* | 13.3 ± 2.4 * | |
| 21 | DM Vehicle | 7.30 ± 0.08 $ , ǂ | 33.7 ± 7.4 | 84.7 ± 5.3 | 17.6 ± 3.9 | 128 ± 10 | 88 ± 2.3 | 1.88 ± 0.74 | 21.0 ± 2.8 |
| DM DAPA | 7.25 ± 0.09 $ , ǂ | 34.2 ± 7.2 | 85.0 ± 23 | 16.0 ± 4.6 | 117 ± 15 | 82 ± 20 | 2.13 ± 0.82 | 14.9 ± 3.3 | |
| Experimental protocol #2 | |||||||||
| 21 | DM Vehicle | 7.46 ± 0.09 | 38.4 ± 4.2 | 66.7 ± 5.5 | 27.9 ± 7.4 | 154 ± 6.8 | 86 ± 2.5 | 2.0 ± 0.5 | 28.9 ± 3.6 |
| DM DAPA | 7.41 ± 0.04 # | 34.6 ± 5.3 # | 70.8 ± 7.5 | 22.4 ± 2.7 # | 143 ± 11 # | 87 ± 4.5 | 1.8 ± 0.7 | 16.5 ± 3.5 # | |
| 50 | DM Vehicle | 7.41 ± 0.03 | 41.2 ± 3.9* | 170.9 ± 26.7* | 25.9 ± 1.7 | 155 ± 5.5 | 97 ± 1.7* | 1.8 ± 0.6* | 28.9 ± 4.6 |
| DM DAPA | 7.40 ± 0.08 # | 38.3 ± 3.2 # , * | 188.9 ± 15.6* | 23.9 ± 5.0 # | 147 ± 8.9 # | 97 ± 0.6* | 1.5 ± 0.4* | 15.7 ± 4.3 # | |
| 21 | DM Vehicle | 7.45 ± 0.07 | 37.2 ± 2.7 | 75.1 ± 8.3 | 26.7 ± 6.2 | 156 ± 4.6 | 89 ± 2.9 | 2.5 ± 0.4 | 28.7 ± 1.5 |
| DM DAPA | 7.40 ± 0.05 # | 35.3 ± 3.8 # | 75.6 ± 6.6 | 22.4 ± 2.4 # | 146 ± 7.6 # | 87 ± 3.0 | 2.1 ± 0.7 | 16.0 ± 4.4 # | |
#
p < 0.05 versus DM vehicle.
$
p < 0.05 versus Control DAPA.
ǂ
p < 0.05 versus Control vehicle.
*
p < 0.05 versus 21%.