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Voltage-dependent activity of Kv1.3 channels expressed in Xenopus laevis oocytes. Two-electrode voltage clamp electrophysiology showed Acan1 (purple) inhibited human Kv1.3 expressed in X. laevis oocytes with a 15,000-fold less IC50 value of 829.85 nM than the positive control ShK (IC50 of 57.4 pM, data not shown). Nak1 (green) had little efficacy and potency on Kv1.3, tested up to 10 μM. Data show mean ± SEM of a representative experiment, n = 5.
