TABLE 1.

Summary of VITT cases reported in literature

First Author	Case no.	Sex	Age (y)	Days after vaccination	Site of thrombosis	Platelet count (mm3)	Thrombotic risk factors	Anti‐PF4 ab testing b	Treatment	Outcome
Greinacher 34	1	Female	49	5	CVT, SVT, PE, AT	13 000	– a	Positive	Heparin	Died
	2	Female	35	6	PE	107 000	–	Positive	LMWH	Alive
	3	Female	48	9	CVT	60 000	–	Positive	NA	NA
	4	Female	35	7	CVT	9000	–	Positive	Heparin	Died
	5	Female	43	13	CVT, SVT, PE, DVT right intraventricular	23 000	FVL, ACL‐Ab	Positive	Heparin	Alive
	6	Female	22	7	CVT	75 000	–	NA	NA	Alive
	7	Female	36	8	CVT	29 000	–	NA	Heparin	Alive
	8	Female	46	8	CVT	16 000	–	Positive	‐	Died
	9	Female	24	16	CVT	13 000	–	Positive	‐	Died
	10	Male	NA	11	CVT, SVT	8000	–	Positive	‐	Died
	11	Male	NA	12	NA	NA	NA	Positive	‐	Died
Schultz 35	1	Female	37	8	CVT	22 000	Hormonal contraception	Positive	LMWH, PLTS	Died
	2	Female	42	10	CVT	14 000	Hormonal contraception	Positive	LMWH, PLTS, steroids, IVIG	Died
	3	Male	32	7	SVT	10 000	–	Positive	LMWH, PLTS, steroids, IVIG	Alive
	4	Female	39	10	CVT	70 000	–	Positive	LMWH, steroids, IVIG	Alive
	5	Female	54	7	CVT	19 000	Hormonal replacement tp	Positive	Heparin, PLTS, steroids, IVIG	Died
Franchini 36	1	Male	50	7	CVT	15 000	MTHFR het	Positive	PLTS	Died
Scully 37	1	Female	30	13	CVT, SVT, PE, II	27 000	– c	Positive	NA	Alive
	2	Female	55	6	SVT, AT	11 000	–	Positive	NA	Died
	3	Female	26	12	CVT	64 000	–	Positive	NA	Alive
	4	Female	52	10	CVT, PE, II	31 000	–	Positive	NA	Died
	5	Male	38	14	PE	16 000	–	Positive	NA	Died
	6	Female	49	15	CVT	14 000	–	Positive	NA	Alive
	7	Male	25	9	CVT	19 000	–	Positive	NA	Died
	8	Male	32	19	CVT	87 000	–	Positive	NA	Alive
	9	Female	35	9	CVT	65 000	–	Positive	NA	Alive
	10	Male	77	8	PE	NA	–	Positive	NA	Alive
	11	Male	66	12	DVT	34 000	–	± d	NA	Alive
	12	Male	34	14	CVT	23 000	–	Positive	NA	Alive
	13	Male	54	10	SVT, MI	71 000	–	Positive	NA	Died
	14	Female	71	14	No thrombosis	17 000	–	Positive	NA	Alive
	15	Female	22	10	CVT	100 000	–	Positive	NA	Died
	16	Female	39	10	MCAI	57 000	–	Positive	NA	Alive
	17	Female	70	17	DVT, PE	28 000	–	Positive	NA	Alive
	18	Male	21	10	MCAI	113 000	–	Positive	NA	Alive
	19	Female	46	14	CVT	7000	–	Positive	NA	Alive
	20	Female	32	12	CVT	98 000	–	Positive	NA	Died
	21	Male	48	14	CVT	16 000	–	Positive	NA	Alive
	22	Female	49	24	PE	61 000	–	Positive	NA	Alive
	23	Female	46	10	CVT	36 000	–	Negative	NA	Alive

Abbreviations: ab, antibody; ACL‐Ab, anticardiolipin antibodies; AT, aortic thrombosis; CVT, cerebral vein thrombosis; DVT, deep vein thrombosis; FVL, factor V Leiden; II, intestinal infarct; IVIG, intravenous immunoglobulin; LMWH, low molecular weight heparin; MCAI, middle cerebral artery infarct; MI, myocardial infarction; MTHFR het, heterozygosity for methylene tetrahydrofolate reductase C677T polymorphism; NA, data not available; PE, pulmonary embolism; PLTS, platelet concentrates; SVT, splanchnic vein thrombosis; tp, therapy.

^a Three out of the nine women were under hormonal contraception.

^b Testing for anti‐PF4 antibodies performed by means of enzyme‐linked immunosorbent assay (ELISA).

^c One out of the 14 women were under oral contraceptive pill. Tests for thrombophilia were negative. A test for lupus anticoagulant was positive in 5 of the 10 patients for whom results were available.

^d Equivocal result.