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. 2021 May 11;48(9):1166–1172. doi: 10.1111/cup.14038

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© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Histopathologic findings of second lesional biopsy specimen on hospitalization Day 12. The biopsy displays features similar to those seen on the patient's initial biopsy: A, H&E sections reveal epidermal necrosis and dilated papillary dermal vessels with intraluminal thrombi despite current therapeutic anticoagulation (×100). B, A deep dermal vessel with thrombosis admixed with inflammatory cell debris (×400). C, Phosphotungstic acid hematoxylin (PTAH) stain highlights fibrin‐rich thrombi staining blue within a vessel (×400). Platelet markers, D, CD61 (×400) and, E, CD41 (×400) reveal platelet aggregation within vessel lumina with predominant aggregation at the vessel periphery. F, Complement split product C4d is diffusely present along the walls of vessel lumina (×400)