. 2021 May 27;297(1):100836. doi: 10.1016/j.jbc.2021.100836

Table 4.

Rate of force redevelopment (k_tr, s⁻¹) for NTg fibers permeabilized with hS2 proteins

hS2 Proteins	n	Fibers^control	Fibers^PKA	Fibers^{λ-phosphatase}
Control	5	7.86 ± 0.46	6.42 ± 0.16	4.13 ± 0.32^{¶¶¶,††}
hS2^Wt	5	20.4 ± 1.24∗∗∗	5.84 ± 0.29^¶¶¶	14.17 ± 0.92∗∗∗^{,¶¶¶,†††}
hS2^R870H	5	10.22 ± 0.62^§§§	11.69 ± 1.06∗∗∗^,§§§	4.07 ± 0.29^{§§§,¶¶¶,†††}
hS2^E924K	5	7.94 ± 0.83^§§§	20.36 ± 0.6∗∗∗^{,§§§,¶¶¶}	4.49 ± 0.48^{§§§,†††}
hS2^E930Δ	5	9.51 ± 0.75^§§§	14.25 ± 0.85∗∗∗^,§§§,¶¶	4.16 ± 0.30^{§§§,¶¶¶,†††}

Abbreviation: NTg, nontransgenic.

Statistical significance was calculated by ordinary one-way ANOVA with Tukey’s multiple comparison test with single pooled variance. ± values are indicative of the SEM for observed k_tr values. ‘n’ is equal to the number of skinned papillary fibers used for the measurements, where one fiber per animal was utilized (12-week-old NTg mice, FVB/N and mixed sex) and measured k_tr values at submaximal pCa 5.7 and sarcomere length 2.0 μM. See Table 7 for analysis of main factors and interactions.

∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 versus control.

^§p < 0.05, ^§§p < 0.01, ^§§§p < 0.001 versus hS2^Wt.

^¶p < 0.05, ^¶¶p < 0.01, ^¶¶¶p < 0.001 versus respective Fibers^control.

^†p < 0.05, ^††p < 0.01, ^†††p < 0.001 versus respective Fibers^PKA.