. 2021 May 27;297(1):100836. doi: 10.1016/j.jbc.2021.100836

Table 5.

The k_tr for fibers of AAA and DDD transgenic mice treated with hS2 proteins

hS2 Proteins	n	AAA-Tg fiber	DDD-Tg fiber
Control	5	3.36 ± 0.37	5.52 ± 0.25^¶
hS2^Wt	5	5.69 ± 0.20∗∗∗	5.3 ± 0.44
hS2^R870H	5	4 ± 0.27^§§	8.48 ± 0.34∗∗^,§§,¶¶¶
hS2^E924K	5	2.57 ± 0.31^§§§	10.74 ± 0.85∗∗∗^{,§§§,¶¶¶}
hS2^E930Δ	5	3.22 ± 0.29^§§§	10.36 ± 0.49∗∗∗^{,§§§,¶¶¶}

Abbreviation: Tg, transgenic.

Statistical significance was calculated by ordinary one-way ANOVA with Tukey’s multiple comparison test with single pooled variance. ‘n’ is equal to the number of skinned papillary fibers used for each measurement, where one papillary fiber was utilized per animal (12 weeks old, FVB/N, and mixed sex). ± values are the SEM for measured k_tr values at submaximal pCa 5.7 and sarcomere length 2.0 μM. See Table 7 for analysis of main factors and interactions.

∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 versus control.

^§p < 0.05, ^§§p < 0.01, ^§§§p < 0.001 versus hS2^Wt.

^¶p < 0.05, ^¶¶p < 0.01, ^¶¶¶p < 0.001 versus respective AAA-Tg fibers.