Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 7;7(5):459–470. doi: 10.1002/cjp2.220

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland & John Wiley & Sons, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Quantitative assessment of inflammation in COVID‐19 and seasonal influenza. Representative paired regions showing hematoxylin and eosin (H&E) staining along with CD20, CD8, and CD3 immunostains (clockwise from H&E) for (A) influenza and (B) COVID‐19. The distribution of T‐cells and relative abundance of CD8‐positive cells relative to CD3 is comparable. (C,D) Representative ROI analysis for CD3 and CD8 immunostains in a case of (C) fatal influenza and (D) COVID‐19. (E,F) Graphical representation of individual CD4:CD8 ratios per ROI (E) and cumulative CD4:CD8 ratios per patient (F). Note that there is no significant difference of CD4:CD8 ratios between COVID‐19 and influenza, although there is a trend toward higher CD4:CD8 for COVID‐19. In Figure 1E, individual patients are identified by a unique shape on the graph for each disease.