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. 2021 Jun 28;326(3):1–10. doi: 10.1001/jama.2021.9199

Figure 3. Effect of Ranitidine and Diet on Cumulative Excretion of NDMA in Urine Over 24 Hours.

Figure 3.

Paired differences in cumulative excretion of N-nitrosodimethylamine (NDMA) in urine over 24 hours. At each listed time point on the x-axis since study drug administration (ie, 0 [pre-dose], 3, 6, 9, 12, 15, and 24 hours), the y-axis shows the median (point) and interquartile range (lines) of the paired differences in cumulative NDMA excretion between the 2 specific treatment groups up until that time point. Note that the median and interquartile range of the paired differences is calculated by first determining the difference between 2 treatments for each individual participant and then determining the median and interquartile range of those values. Ranitidine or placebo was administered at 0 hours. Meals were administered at 0, 4, 7.5, and 11.5 hours. Individual participant profiles for each treatment group are shown in eFigure 1 in Supplement 2.