4. Measurement of symptomatic urinary tract infection.

TrialID	Outcome as defined by trial authors	Trial definition	Relevant definition outlined by International Guideline Panel
Ahmed 2014	Symptomatic UTI	Significant bacteriuria with at least one of the following symptoms: dysuria, frequency of micturition, urgency, suprapubic pain ir burning sensation at micturition	CDC
Alessandri 2006	UTI	Significant bacteria which is determined by: urine culture and defined as at least 105 cfu/mL	EAU: symptomatic bacteriuria
Allen 2016	UTI	Not reported	N/A
Alonzo‐Sosa 1997	UTI	Defined as a positive urine sample associated with: dysuria, polyuria, incomplete emptying, pain, fever or sepsis. A positive urine sample was defined as the presence of > 105 cfu/mL if MSU and 104 cfu/mL in a catheter sample.	CDC
Aref 2020	Symptomatic UTI	“The diagnosis of symptomatic urinary tract infection was based on the following criteria: significant bacteriuria with at least one of the following symptoms; dysuria, frequency of micturition, urgency, supra pubic pain, or burning sensation at micturition.”	CDC
Aslam 2019	UTI	Not reported	N/A
Azarkish 2003	UTI	Not reported	N/A
Azarkish 2005	Not reported	Not reported	N/A
Barone 2015	UTI	Not reported	N/A
Basbug 2020	Significant bacteruria	Significant microscopic bacteriuria was defined as ≥ 100,000 bacteria/ mL MSU	EAU: asymptomatic bacteriuria
Benoist 1999	UTI	Culture yield of > 105 cfu/mL with or without symptoms	With symptoms: CDC Without symptoms: EAU definition for "Asymptomatic bacteriuria"
Bristoll 1989	Not reported	Not reported	N/A
Carpiniello 1988	UTI	Culture yield of 105 cfu/mL	EAU: asymptomatic bacteriuria
Carter‐Brooks 2018	UTI	Defined as a positive culture or symptoms and antibiotic treatment	N/A
Chai 2011	Symptomatic UTI	Positive urine culture: > 105 cfu/mL of an identified single uropathogen/mL of urine Symptomatic UTI: fever (> 38 °C) and dysuria with a positive urine culture	CDC
Chen 2013	CAUTI	CDC criteria used to define symptomatic UTI and asymptomatic bacteriuria	CDC
Chia 2009	CAUTI	Not reported	N/A
Chillington 1992	Not reported	N/A	N/A
Cornia 2003	CAUTI	Growth from a urine specimen aseptically aspirated from the catheter of ≥ 100 cfu of a predominant pathogen OR ≥ 10 leukocytes per high‐power field on urinalysis in a patient with a clinical diagnosis of UTI	N/A
Coyle 2015	Bacteriuria	Symptomatic or asymptomatic bacteriuria used. No definition given	N/A
Crowe 1993	Not reported	N/A	N/A
Dunn 1999	Not reported	N/A	N/A
Dunn 2000b	UTI	Not reported	N/A
Dunn 2003	UTI	Determined by either microscopic abnormality or any patient symptoms	N/A
Durrani 2014	UTI	Not reported	N/A
El‐Mazny 2014	Significant bacteriuria	Significant bacteriuria: > 105 cfu/mL of urine in a MSU sample collected 24 h post‐op	EAU: asymptomatic bacteriuria
Ganta 2005	Not reported	N/A	N/A
Glavind 2007	Positive urine culture	Defined as the presence of ≥ 105 cfu/mL	EAU: asymptomatic bacteriuria
Gong 2017	Symptomatic UTI	Defined as bacteriuria with fever, frequent or painful urination or burning on urination	CDC
Gross 2007	UTI	Used CDC criteria	CDC
Gungor 2014	Not reported	N/A	N/A
Guzman 1994	UTI	Urine culture of > 105 cfu/mL reported as outcome. Definition is not provided	EAU: asymptomatic bacteriuria
Hakvoort 2004	UTI	Signs of UTI: having > 10 WBC/high‐powered field and significant microscopic bacteriuria (1/high‐powered field) in the urine sediment UTI: presence of > 105 cfu/mL in urine culture	EAU: asymptomatic bacteriuria
Hall 1998	Not reported	N/A	N/A
Han 1997	Not reported	N/A	N/A
Hewitt 2001	Not reported	N/A	N/A
Huang 2011	UTI	Not reported	N/A
Ind 1993	Not reported	N/A	N/A
Irani 1995	UTI	Not reported	N/A
Iversen Hansen 1984	Not reported	N/A	N/A
Jang 2012	Not reported	N/A	N/A
Jeong 2014	Not reported	N/A	N/A
Joshi 2014	Symptomatic UTI	Symptomatic UTI: based on the presence of significant bacteriuria accompanied by at least 1 of the following symptoms: fever, dysuria, increased frequency of micturition, urinary urgency, suprapubic pain and dysuria	CDC
Jun 2011	Not reported	N/A	N/A
Kamilya 2010	Symptomatic UTI	Symptomatic UTI: positive urine culture of > 105 cfu/mL plus 1 of the following symptoms: dysuria, fever (> 38 °C) or rigors	CDC
Kelleher 2002	Not reported	N/A	N/A
Kim 2012	Not reported	N/A	N/A
Koh 1994	UTI	Not reported	N/A
Kokabi 2009	UTI	Not reported	N/A
Lang 2020	UTI	Not reported	N/A
Lau 2004	Positive urine culture	Not reported	N/A
Li 2014	Infection	Not reported	N/A
Liang 2009	UTI	UTI: positive urine culture of > 105 cfu/mL. However, treatment was only given for positive urine cultures if participant had adverse urinary symptoms or post‐op pyrexia (> 38 °C)	CDC
Lista 2020	UTI	Not reported	N/A
Liu 2015	Not reported	N/A	N/A
Lyth 1997	Not reported	N/A	N/A
Mao 1994	Not reported	N/A	N/A
Matsushima 2015	Not reported	N/A	N/A
McDonald 1999	Not reported	N/A	N/A
Naguimbing‐Cuaresma 2007	Not reported	N/A	N/A
Nathan 2001	Positive catheter specimen urine (CSU)	Not reported	N/A
Nguyen 2012	Not reported	N/A	N/A
Nielson 1985	Not reported	N/A	N/A
Noble 1990	Not reported	N/A	N/A
Nyman 2010	Not reported	N/A	N/A
Oberst 1981	Not reported	N/A	N/A
Onile 2008	Significant bacteriuria	Significant bacteriuria: positive urine culture of > 105 cfu/mL in a sample of MSU collected 72 h post‐op with signs of a fever ( a temperature of > 38 °C on 2 occasions within 10 days of the procedure, excluding the first 24 h)	CDC
Ouladsahebmadarek 2012	Symptomatic UTI	Not reported	N/A
Pervaiz 2019	UTI	Urine sample was obtained to assess UTI (bacterial colony count > 105 cfu/mL on urine culture after removal of catheter assessed on day 7)	EAU: catheter‐associated asymptomatic bacteriuria
Popiel 2017	UTI	Not reported	N/A
Rajan 2017	UTI	Urinary infections defined as when microscopic examination of the urine revealed pus cells or when urine culture showed growth of pathogenic organisms	N/A
Ruminjo 2015	Not reported	N/A	N/A
Sahin 2011	Not reported	N/A	N/A
Sandberg 2019	UTI	Standard urine test for nitrite and leucocytes in combination with clinical symptoms	Not clear whether test is dipstick only or whether it involves microscopy/culture
Schiotz 1995	UTI	Positive cultures: culture of > 105 cfu/mL in a sample of MSU or CSU culture of > 104 cfu/mL UTI: positive urine culture in the absence of symptoms. Patients were defined as having UTI if there was any doubt	EAU: asymptomatic bacteriuria
Schiotz 1996	UTI	Positive cultures: culture of > 105 cfu/mL in a sample of MSU or CSU culture of > 104 cfu/mL UTI: positive urine culture in the absence of symptoms. Participants were defined as having UTI if there was any doubt	EAU: asymptomatic bacteriuria
Sekhavat 2008	Positive urine culture	Positive urine culture: prevalence of symptomatic UTI was confirmed through a positive urine culture OR through signs of UTI such as: frequency, urgency, dysuria, suprapubic pain or fever	Does not fully meet the criteria for CDC. Must be positive cultures AND clinical features
Shahnaz 2016	Positive urine culture	The presence of positive urinary culture or > 100,000 colony counts in each mL of urine or > 10 pieces of leukocyte in each microscopy field was considered as a urinary infection.	EAU: asymptomatic bacteriuria
Shrestha 2013	Asymptomatic bacteriuria	Asymptomatic bacteriuria: pus cells of > 5 per high‐power field in routine examination of urine and bacterial culture positive	EAU: asymptomatic bacteriuria
Souto 2004	Not reported	N/A	N/A
Sun 2004	UTI	UTI: positive urine culture of > 105 cfu/mL or WBC > 5/high‐power field in urine analysis	EAU: asymptomatic bacteriuria
Tahmin 2011	UTI	UTI: positive urine culture of > 105 cfu/mL	EAU: asymptomatic bacteriuria
Talreja 2016	Not reported	N/A	N/A
Taube 1989	Not reported	N/A	N/A
Toscano 2001	Not reported	N/A	N/A
Valero Puerta 1998	Not reported	N/A	N/A
Vallabh‐Patel 2020	UTI	For the purpose of this trial, participants were considered positive for a UTI if they had (1) positive urine cultures per CDC guidelines or (2) treated empirically over the phone for symptoms of UTI, even in the absence of a urine culture	CDC
Webster 2006	Not reported	N/A	N/A
Weemhoff 2011	UTI	UTI: > 25 WBC/high‐power field, nitrate production, > 20 bacteria/high‐power field, positive urine culture of > 105 cfu/mL	EAU: asymptomatic bacteriuria
Williamson 1982	Not reported	N/A	N/A
Wilson 2000	Not reported	N/A	N/A
Wu 2015	Not reported	N/A	N/A
Wyman 1987	Not reported	N/A	N/A
Yaghmaei 2017	Not reported	N/A	N/A
Yee 2015	Not reported	N/A	N/A
Zaouter 2009	UTI	UTI: pyrexia of > 38 °C, clinical features of UTI (dysuria, frequency, urgency, suprapubic pain, urinary incontinence) and a positive urine culture (107 bacterial colonies of micro‐organism‐forming units/L within 2 weeks after the removal of bladder catheter)	CDC EAU: complicated UTI
Zhou 2012	Not reported	Defined as post‐catheter removal MSU clean catch culture of ≥ 104 cfu/mL for Gram positive organisms or ≥ 105 cfu/mL for Gram negative organisms	EUA: asymptomatic bacteriuria
Zmora 2010	UTI Asymptomatic bacteriuria	UTI: positive urine culture and symptoms suggestive of UTI	CDC
Zomorrodi 2018	UTI	Not reported	N/A

CAUTI: catheter‐associated urinary tract infection; CDC: Centers for Disease Control and Prevention; cfu: colony forming unit; CSU: catheter specimen urine; EAU: European Association of Urology; MSU: midstream urine; N/A: not applicable; UTI: urinary tract infection; WBC: white blood count