Skip to main content
. 2021 Jun 28;78(8):972–981. doi: 10.1001/jamaneurol.2021.1910

Table 2. Mean Change From Baseline to 6-Month Outcomes for Rating Scales and Levodopa Equivalent Daily Dose Valuesa.

Rating scale Standard of care or some expert care Home health care P value
Participants, No. Mean (SD) score Participants, No. Mean (SD) score
Standard of care vs home health care
UPDRS III off-medication 14 −5.3 (14.3) 16 −13.4 (12.6) .27
UPDRS III on-medication 15 −2.7 (12.7) 16 −0.4 (9.6) .90
Total UPDRS off-medicationb 13 −0.8 (20.2) 16 −16.9 (15.7) .08
PDQ-39 12 −3.9 (23.4) 15 −9.0 (15.5) .97
Multidimensional Caregiver Strain Index score 5 −4.2 (11.2) 12 −1.3 (6.7) .53
Levodopa equivalent daily dose, mg 17 −86.8 (397.0) 17 −70.5 (438.2) .91
Some expert care vs home health care only
UPDRS III off-medication 17 −5.1 (13.1) 13 −15.6 (12.8) .20
UPDRS III on-medication 18 −1.3 (12.2) 13 −1.8 (9.7) .85
Total UPDRS off-medicationb 16 −1.6 (18.7) 13 −19.5 (15.5) .04
PDQ-39 15 −5.0 (21.1) 12 −8.9 (17.2) .90
Multidimensional Caregiver Strain Index score 7 −3.4 (9.3) 10 −1.3 (7.4) .42
Levodopa equivalent daily dose, mg 20 −26.9 (428.6) 14 −152.5 (389.8) .40

Abbreviations: PDQ-39, 39-question Parkinson’s Disease Questionnaire; UPDRS, Unified Parkinson’s Disease Rating Scale; UPDRS III, Unified Parkinson’s Disease Rating Scale part III.

a

Negative values imply improvement in parkinsonian symptom severity (UPDRS and PDQ-39 scores), lowered caregiver strain (Multidimensional Caregiver Strain Index scores), or reduced levodopa equivalent daily doses. Grouping was done by both study arm and comparing patients who underwent at least 1 clinic deep brain stimulation postoperative management visit compared with those exclusively managed by home health. The UPDRS scores recorded at baseline were in the off-stimulation state, while 6-month outcomes were recorded in the on-stimulation state.

b

The total UPDRS is the sum of parts I, II, III, and IV.