Table 2. Mean Change From Baseline to 6-Month Outcomes for Rating Scales and Levodopa Equivalent Daily Dose Valuesa.
Rating scale | Standard of care or some expert care | Home health care | P value | ||
---|---|---|---|---|---|
Participants, No. | Mean (SD) score | Participants, No. | Mean (SD) score | ||
Standard of care vs home health care | |||||
UPDRS III off-medication | 14 | −5.3 (14.3) | 16 | −13.4 (12.6) | .27 |
UPDRS III on-medication | 15 | −2.7 (12.7) | 16 | −0.4 (9.6) | .90 |
Total UPDRS off-medicationb | 13 | −0.8 (20.2) | 16 | −16.9 (15.7) | .08 |
PDQ-39 | 12 | −3.9 (23.4) | 15 | −9.0 (15.5) | .97 |
Multidimensional Caregiver Strain Index score | 5 | −4.2 (11.2) | 12 | −1.3 (6.7) | .53 |
Levodopa equivalent daily dose, mg | 17 | −86.8 (397.0) | 17 | −70.5 (438.2) | .91 |
Some expert care vs home health care only | |||||
UPDRS III off-medication | 17 | −5.1 (13.1) | 13 | −15.6 (12.8) | .20 |
UPDRS III on-medication | 18 | −1.3 (12.2) | 13 | −1.8 (9.7) | .85 |
Total UPDRS off-medicationb | 16 | −1.6 (18.7) | 13 | −19.5 (15.5) | .04 |
PDQ-39 | 15 | −5.0 (21.1) | 12 | −8.9 (17.2) | .90 |
Multidimensional Caregiver Strain Index score | 7 | −3.4 (9.3) | 10 | −1.3 (7.4) | .42 |
Levodopa equivalent daily dose, mg | 20 | −26.9 (428.6) | 14 | −152.5 (389.8) | .40 |
Abbreviations: PDQ-39, 39-question Parkinson’s Disease Questionnaire; UPDRS, Unified Parkinson’s Disease Rating Scale; UPDRS III, Unified Parkinson’s Disease Rating Scale part III.
Negative values imply improvement in parkinsonian symptom severity (UPDRS and PDQ-39 scores), lowered caregiver strain (Multidimensional Caregiver Strain Index scores), or reduced levodopa equivalent daily doses. Grouping was done by both study arm and comparing patients who underwent at least 1 clinic deep brain stimulation postoperative management visit compared with those exclusively managed by home health. The UPDRS scores recorded at baseline were in the off-stimulation state, while 6-month outcomes were recorded in the on-stimulation state.
The total UPDRS is the sum of parts I, II, III, and IV.