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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Radiat Res. 2021 Mar 1;195(3):301–306. doi: 10.1667/RADE-20-00221.1

FIG. 1.

FIG. 1.

Bone marrow cells from mice that have defects in immunosurveillance remain sufficient to suppress radiation-induced lymphomagenesis in the thymus. Four-week-old B6.SJL (CD45.1) mice received one dose of 1.8 Gy TBI for four consecutive weeks. Bone marrow transplantation was performed 6 h after final TBI. Each recipient was injected intravenously with 1 × 107 bone marrow cells from mice on a CD45.2 background. Both male and female mice were used. Panel A: Lymphoma-free survival of irradiated mice that received bone marrow cells from wild-type (WT), TNFα−/− or IFNγ−/− mice. Irradiated mice that did not receive bone marrow cells (No BMT) were used as a positive control for the development of radiation-induced thymic lymphoma. The lines of irradiated mice that received bone marrow cells from WT, TNFα−/− or IFNγ−/− mice are superimposed. P Value was calculated using log-rank test. Panel B: Lymphoma-free survival of irradiated mice that received bone marrow cells from either PRF1−/− mice or did not receive bone marrow cells. P value was calculated using log-rank test.