Skip to main content
. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Radiat Res. 2021 Mar 1;195(3):301–306. doi: 10.1667/RADE-20-00221.1

TABLE 1.

Summary of Results of the Bone Marrow Transplantation Experiments

Bone marrow Inhibit thymic
donors Biological defects lymphoma?
Wild-type (C57BL6)

  • N/A

 Yes
TNFα−/−

  • Defects in TNFα-mediated signaling

 Yes
IFNγ−/−

  • Impaired function of cytotoxic lymphocytes

  • Mice lacking IFNγ have an increase in spontaneous lymphoma formation

 Yes
PRF1−/−

  • Impaired function of cytotoxic lymphocytes

  • Mice lacking PRF1 have an increase in spontaneous lymphoma formation

 Yes
Rag2−/−; γc−/−

  • Cannot produce mature T, B and NK cells

  • Thymocyte differentiation stops at DN2

 No
Rag2−/−

  • Cannot produce mature T and B cells

  • Thymocyte differentiation stops at DN3

 No
IgM−/−

  • Cannot produce mature B cells

  • Normal T-cell differentiation

 Yes