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. 2021 Jun 28;27(24):3581–3594. doi: 10.3748/wjg.v27.i24.3581

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Fasudil prevents thioacetamide-induced liver fibrosis. A: Histological observation of collagen deposition by sirius red staining under a light-field microscope with × 100 magnification (left). Quantitative analysis of sirius red staining of each group (right); B: Expression of alpha smooth muscle actin (a-SMA) and collagen I in liver tissues was assayed by western blotting. Right panel shows the quantification of α-SMA and collagen I protein levels; C: Levels of matrix metalloproteinase 2 (MMP2) and MMP9 mRNA in liver tissues were detected by real time-reverse transcription polymerase chain reaction (RT-PCR); D: Hepatic expression of transforming growth factor beta 1 (TGF-β1) mRNA was detected by real time-RT-PCR, the secretion level of TGF-β1 in serum was assayed by enzyme-linked immunoassay. Data represent the mean ± SD from at least three independent experiments. ^aP < 0.05, ^bP < 0.01.