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Antibody-mediated TRALI induces alteration of the alveolar-capillary barrier in mice. (A) Lung wet weight/dry weight ratio ratios in untreated control, isotype control and TRALI mice. (B) Total protein concentrations in lung homogenates. Data are expressed as the mean ± standard deviation (n=6 mice/group). *P<0.05, ****P<0.0001, by one-way ANOVA followed by Tukey's multiple-comparison test. TRALI, transfusion-related acute lung injury; LPS, lipopolysaccharide.
