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. 2021 Jun 23;24(2):601. doi: 10.3892/mmr.2021.12239

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Antibody-mediated TRALI reduces platelets in the peripheral blood and platelets accumulation in the lungs. (A) Numbers of peripheral blood platelets in untreated control, isotype control and TRALI mice. (B) Representative immunostaining for CD41a in untreated, isotype control and TRALI mice. Red, CD41a; blue, DAPI. Scale bar, 20 µm; original magnification, ×400. (C) The average CD41a immunofluorescence luminosity was determined using Image-Pro Plus 6.0 software. A total of six replicates were included in each group and the most representative images are shown. Data are shown as the mean ± standard deviation (n=6 mice/group). *P<0.05, **P<0.01, ****P<0.0001. One-way ANOVA variance of peripheral blood platelets and pulmonary platelets followed by Tukey's multiple-comparison test and Newman-Keuls multiple-comparison test, respectively. TRALI, transfusion-related acute lung injury; PLT, platelet.