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. 2021 Jun 29;14:29. doi: 10.1186/s13072-021-00399-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Experimental QC and Hi-C replicate concordance. A Western blot for gfp and clamp RNAi Hi-C experiments indicating successful knockdown of CLAMP protein (

source data provided as Additional file 1: Source Data file). B Pairwise Hi-C replicate concordance scores as measured by GenomeDISCO (source data provided as Additional file 1: Source Data file). C Per chromosome KR balanced matrices for gfp RNAi (top), clamp RNAi (middle), and clamp vs gfp RNAi (bottom). Each chromosome is shown at 50 kb resolution. D The per chromosome distribution of high-confidence Hi-C interactions (source data provided in Additional file 5: Table S3 and Additional file 1: Source Data file). E The distribution of X-chromosome high-confidence Hi-C interactions that involve a CES and matched control (randomized active chromatin regions) (source data provided as Additional file 1: Source Data file)