Table 1.
AD specific proteins detected by fully tryptic peptides (TRYP) and/or fully tryptic phosphopeptides (STYP) that show a Chi Square (χ2) value of ≥ 43. The average Chi Square (χ2) value per gene symbol was computed in R
| Gene_symbol | TRYP_X2 | Proteins | Gene_symbol | STYP_X2 | Proteins |
|---|---|---|---|---|---|
| KIF12 | 170 | 2 | MOK | 151 | 1 |
| DISC1 | 104 | 29 | SMIM19 | 96 | 2 |
| OR8B12 | 96 | 1 | NXNL1 | 94 | 1 |
| ZC3H12A | 94 | 1 | SLC24A2 | 85 | 2 |
| TNF | 81 | 3 | CUX1 | 78 | 1 |
| TBC1D8B | 74 | 1 | AHRR | 74 | 1 |
| GALNT3 | 74 | 1 | C10orf90 | 74 | 1 |
| EME2 | 74 | 1 | MAEA | 74 | 1 |
| CD1B | 74 | 1 | SRSF8 | 74 | 1 |
| BAG1 | 73 | 2 | TBATA | 74 | 1 |
| CPSF2 | 68 | 2 | TNIK | 74 | 1 |
| MMP15 | 65 | 1 | UBE2G1 | 74 | 2 |
| DNAJC2 | 65 | 3 | PDE4C | 70 | 10 |
| PHACTR4 | 64 | 1 | PCGF2 | 69 | 2 |
| OR8B3 | 64 | 1 | KIR3DP1 | 65 | 1 |
| GCK | 64 | 1 | TJP2 | 65 | 1 |
| EXOSC7 | 64 | 1 | CPNE8 | 63 | 2 |
| HMGA1 | 63 | 4 | NGF | 59 | 1 |
| NT5C3A | 63 | 2 | ZNF671 | 57 | 2 |
| POLR1A | 59 | 1 | ADAMTS12 | 54 | 1 |
| NET1 | 57 | 1 | APC | 54 | 1 |
| MGC24039 | 57 | 1 | ASAH2B | 54 | 1 |
| SYTL4 | 56 | 2 | BRCA1 | 54 | 1 |
| CLDN7 | 56 | 2 | C11orf89 | 54 | 1 |
| OSBPL1A | 55 | 2 | CBWD7 | 54 | 1 |
| VTI1B | 54 | 1 | DAPK3 | 54 | 1 |
| TRIM14 | 54 | 1 | DCAF15 | 54 | 1 |
| TPH1 | 54 | 1 | GPR98 | 54 | 1 |
| TNFRSF14 | 54 | 1 | GRID2 | 54 | 1 |
| SORBS3 | 54 | 1 | HSP90AA2 | 54 | 1 |
| SLC30A1 | 54 | 1 | KIAA1467 | 54 | 1 |
| RSRC2 | 54 | 1 | KIR222 | 54 | 1 |
| PDCD5 | 54 | 1 | L3MBTL2 | 54 | 1 |
| PANO | 54 | 1 | LOC389605 | 54 | 1 |
| METTL17 | 54 | 1 | NBS1 | 54 | 1 |
| MATK | 54 | 1 | NPR2 | 54 | 3 |
| ILK | 54 | 1 | OR8H2 | 54 | 1 |
| FLJ00366 | 54 | 1 | PDZD9 | 54 | 1 |
| EPHX3 | 54 | 1 | PTTG2 | 54 | 2 |
| DYM | 54 | 1 | RAD52 | 54 | 1 |
| CSNK2B-LY6G5B-1181 | 54 | 1 | RALGAPA2 | 54 | 1 |
| SPEG | 54 | 4 | SIRPA | 54 | 3 |
| CDH13 | 52 | 5 | SLMAP | 54 | 1 |
| SLC36A2 | 51 | 5 | SRM | 54 | 1 |
| SMPD3 | 51 | 3 | TSPY8 | 54 | 1 |
| WDR82 | 51 | 1 | XP32 | 54 | 1 |
| TRAF4 | 51 | 1 | XPC | 54 | 1 |
| SGK3 | 51 | 1 | RP11-632C17__A.1-001 | 54 | 1 |
| NCAPD3 | 51 | 1 | DENND3 | 51 | 2 |
| GRXCR1 | 51 | 1 | CDC27 | 51 | 1 |
| ANKS6 | 49 | 1 | FLJ32063 | 51 | 1 |
| CYP4A11 | 48 | 8 | LOC100129307 | 51 | 1 |
| EXOC3L4 | 46 | 2 | NOX1 | 51 | 1 |
| POC1A | 46 | 2 | NUP210 | 51 | 1 |
| FUT9 | 46 | 2 | OGFOD3 | 51 | 1 |
| MAP3K19 | 46 | 4 | MST1R | 50 | 1 |
| CHD9 | 46 | 1 | NEUROG2 | 50 | 1 |
| USP30 | 44 | 1 | PTPLA | 50 | 2 |
| DCUN1D2 | 44 | 1 | PRKCD | 49 | 1 |
| BOK | 44 | 1 | MROH9 | 49 | 1 |
| TAGLN2 | 44 | 2 | CHMP3 | 48 | 3 |
| TEX101 | 43 | 3 | C2 | 48 | 9 |
The full set of gene symbols with Chi Square (χ2) ≥ is shown in Additional file 1: Table S1