Table 2.
The STRING analysis of the AD specific protein network where corrected difference in observation frequency and the Chi Square value were both greater than 15 that showed: nodes, 1248; number of edges, 5604; average node degree, 8.98; avg. local clustering coefficient, 0.321; expected number of edges, 5362; PPI enrichment p-value, 0.000516
| Term ID | Term description | Observed gene count | Background gene count | False discovery rate |
|---|---|---|---|---|
| KW-0025 | Alternative splicing | 821 | 10223 | 1.98E-18 |
| KW-0963 | Cytoplasm | 379 | 4972 | 0.0178 |
| GO:0005829 | cytosol | 405 | 4958 | 0.0000291 |
| GO:0044444 | cytoplasmic part | 695 | 9377 | 0.0000291 |
| GO:0005737 | Cytoplasm | 809 | 11238 | 0.0000436 |
| GO:0005622 | Intracellular | 983 | 14286 | 0.0007 |
| GO:0044424 | Intracellular part | 966 | 13996 | 0.0007 |
| GO:0043226 | Organelle | 866 | 12432 | 0.0022 |
| GO:0005623 | Cell | 1092 | 16271 | 0.0029 |
| GO:0044464 | Cell part | 1090 | 16244 | 0.003 |
| GO:0043229 | Intracellular organelle | 848 | 12193 | 0.0034 |
| GO:0043231 | Intracellular membrane-bounded organelle | 729 | 10365 | 0.0096 |
| GO:0044422 | Organelle part | 649 | 9111 | 0.0096 |
| GO:0005768 | Endosome | 85 | 876 | 0.0158 |
| GO:0043227 | Membrane-bounded organelle | 781 | 11244 | 0.0158 |
| GO:0098576 | Lumenal side of membrane | 9 | 29 | 0.0219 |
| GO:0055037 | Recycling endosome | 24 | 164 | 0.024 |
| GO:0044446 | Intracellular organelle part | 627 | 8882 | 0.0287 |
| GO:0071556 | Integral component of lumenal side of endoplasmic reticulum | 8 | 26 | 0.0404 |
| GO:0003824 | Catalytic activity | 435 | 5592 | 0.0028 |
| GO:0005488 | Binding | 830 | 11878 | 0.0174 |
| GO:0008152 | Metabolic process | 696 | 9569 | 0.0108 |
| GO:0051726 | Regulation of cell cycle | 115 | 1129 | 0.0108 |
| GO:0010564 | Regulation of cell cycle process | 76 | 684 | 0.0175 |
| GO:1901990 | Regulation of mitotic cell cycle phase transition | 47 | 351 | 0.0175 |
| GO:0045786 | Negative regulation of cell cycle | 61 | 517 | 0.0186 |
| GO:0010821 | Regulation of mitochondrion organization | 26 | 148 | 0.0187 |
| GO:0044237 | Cellular metabolic process | 637 | 8797 | 0.0187 |
| GO:0044238 | Primary metabolic process | 638 | 8808 | 0.0187 |
| GO:0071704 | Organic substance metabolic process | 657 | 9135 | 0.0187 |
| GO:1901987 | Regulation of cell cycle phase transition | 49 | 385 | 0.0187 |
| GO:0008104 | Protein localization | 172 | 1966 | 0.0208 |
| GO:0007346 | Regulation of mitotic cell cycle | 67 | 608 | 0.0212 |
| GO:0006807 | Nitrogen compound metabolic process | 603 | 8349 | 0.0286 |
| GO:0009056 | Catabolic process | 162 | 1859 | 0.0286 |
| GO:0009987 | Cellular process | 994 | 14652 | 0.0286 |
| GO:0010823 | Negative regulation of mitochondrion organization | 13 | 50 | 0.0286 |
| GO:0044248 | Cellular catabolic process | 147 | 1646 | 0.0286 |
| GO:0048583 | Regulation of response to stimulus | 306 | 3882 | 0.0286 |
| GO:0051641 | Cellular localization | 186 | 2180 | 0.0286 |
| GO:0080134 | Regulation of response to stress | 120 | 1299 | 0.0286 |
| GO:0097190 | Apoptotic signaling pathway | 39 | 295 | 0.0286 |
| GO:1901564 | Organonitrogen compound metabolic process | 401 | 5281 | 0.0286 |
| GO:0032270 | Positive regulation of cellular protein metabolic process | 134 | 1496 | 0.0315 |
| GO:0019538 | Protein metabolic process | 324 | 4194 | 0.0389 |
| GO:0044403 | Symbiont process | 68 | 650 | 0.0389 |
| GO:0007093 | Mitotic cell cycle checkpoint | 24 | 153 | 0.0434 |
| GO:0044260 | Cellular macromolecule metabolic process | 472 | 6413 | 0.0434 |
| GO:0016032 | Viral process | 61 | 571 | 0.0439 |
| GO:0016197 | Endosomal transport | 27 | 185 | 0.0452 |
| GO:0051128 | Regulation of cellular component organization | 191 | 2306 | 0.0452 |
| GO:0051247 | Positive regulation of protein metabolic process | 139 | 1587 | 0.0452 |
| GO:0043170 | Macromolecule metabolic process | 539 | 7453 | 0.0463 |