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. 2021 Jun 28;40:217. doi: 10.1186/s13046-021-02022-5

Fig. 3.

Fig. 3

Formation of a pre-metastatic niche. The formation of a pre-metastatic niche (with both CAFs and TAMs) occurs before metastatic growth and it is promoted by primary tumor-derived soluble factors and exosomes. The specific integrins patterns on the exosome surface may condition the specific cellular targets of such exosomes. Therefore, the molecular signature of the pre-metastatic niche and its site-selective location may be considered as a reflection of the primary tumor molecular signature. Created with BioRender.com