Table 1.
Demographics and clinical data for study participants
| Controls | aDS | pDS | dDS | |
|---|---|---|---|---|
| N | 20 | 40 | 19 | 21 |
| Age-at-analysis, years | 47 (11, 24–64) | 35 (9, 22–57)b | 52 (4, 45–60) | 52 (5, 42–62) |
| % Female | 60% | 40% | 42% | 38% |
| % Mild or moderate ID | 0% | 83% | 79% | 67% |
| CAMCOG scorea | NA | 80/107 (11, 55–96, n = 31) | 70/107 (13.8, 41–92, n = 11)c | 59/107 (13.9, 39–87, n = 10)c |
| mCRT score (immediate)a | NA | 35/36 (1.5, 30–36, n = 30) | 20/36 (11.2, 0–36, n = 12)c | 15/36 (7.9, 0–32, n = 11)c |
| mCRT score (delayed)a | NA | 12/12 (0.9, 8–12, n = 31) | 6/12 (3.8, 0–12, n = 13)c | 4/12 (3.3, 0–12, n = 11)c |
| CSF Aβ42:40 ratio | 0.11 (0.01, 0.08–0.12) | 0.09 (0.02, 0.04–0.12)b | 0.05 (0.01, 0.03–0.08)b | 0.05 (0.01, 0.04–0.08)b |
| CSF p-tau pg/ml | 36 (8, 22–54) | 35 (24, 10–122) | 145 (86, 22–304)b | 158 (82, 31–323)b |
| CSF t-tau pg/ml | 243 (57, 167–366) | 295 (166, 86–671) | 936 (658, 118–2565) b | 959 (500, 212–1988) b |
| CSF NFL pg/ml | NA | 355 (234, 65–1036) | 1071 (767, 313–3123) | 1387 (832, 627–3957) |
Mean values (standard deviation, range) are given for each variable across clinical groups. NA, not available. aIn individuals with mild/moderate intellectual disability (ID) only. bp < 0.05 compared to controls. cp < 0.05 compared to aDS