Table 3.
Polymorphism association analysis with gender incongruence, in different models of inheritance (n = 188, crude analysis)
| Model | Genotype | Cis groups (%) | Trans groups (%) | OR | P | AIC | BIC |
|---|---|---|---|---|---|---|---|
| P1 polymorphism (rs10495747) | |||||||
| Codominant | T/T | 79 (84%) | 67 (71.3%) | 1.00 (reference) | .07 | 263.1 | 276 |
| T/C | 15 (16%) | 26 (27.7%) | 2.05 (1.00–4.19) | ||||
| C/C | 0 (0%) | 1 (1.1%) | NA (0.00–NA) | ||||
| Dominant | T/T | 79 (84%) | 67 (71.3%) | 1.00 (reference) | .034* | 261.9 | 271.7 |
| T/C-C/C | 15 (16%) | 27 (28.7%) | 2.13 (1.05–4.33) | ||||
| Recessive | T/T-T/C | 94 (100%) | 93 (98.9%) | 1.00 (reference) | .25 | 265.1 | 274.8 |
| C/C | 0 (0%) | 1 (1.1%) | NA (0.00–NA) | ||||
| Overdominant | T/T-C/C | 79 (84%) | 68 (72.3%) | 1.00 (reference) | .05* | 262.6 | 272.3 |
| T/C | 15 (16%) | 26 (27.7%) | 2.02 (0.99–4.13) | ||||
| Log-additive | — | — | — | 2.15 (1.07–4.30) | .027* | 261.5 | 271.3 |
| P2 polymorphism (rs2584940) | |||||||
| Codominant | T/T | 43 (45.7%) | 27 (28.7%) | 1.00 (reference) | .039* | 261.9 | 274.9 |
| T/G | 42 (44.7%) | 52 (55.3%) | 2.00 (1.06–3.76) | ||||
| G/G | 9 (9.6%) | 15 (16%) | 2.72 (1.04–7.10) | ||||
| Dominant | T/T | 43 (45.7%) | 27 (28.7%) | 1.00 (reference) | .014* | 260.4 | 270.1 |
| T/G-G/G | 51 (54.3%) | 67 (71.3%) | 2.12 (1.16–3.89) | ||||
| Recessive | T/T-T/G | 85 (90.4%) | 79 (84%) | 1.00 (reference) | .18 | 264.6 | 274.3 |
| G/G | 9 (9.6%) | 15 (16%) | 1.82 (0.75–4.39) | ||||
| Overdominant | T/T-G/G | 52 (55.3%) | 42 (44.7%) | 1.00 (reference) | .14 | 264.3 | 274 |
| T/G | 42 (44.7%) | 52 (55.3%) | 1.54 (0.87–2.74) | ||||
| Log-additive | — | — | — | 1.74 (1.11–2.73) | .013* | 260.3 | 270 |
| P3 polymorphism (rs6756785) | |||||||
| Codominant | A/A | 50 (53.2%) | 32 (34%) | 1.00 (reference) | .03* | 261.4 | 274.4 |
| A/G | 38 (40.4%) | 54 (57.5%) | 2.21 (1.20–4.06) | ||||
| G/G | 6 (6.4%) | 8 (8.5%) | 2.09 (0.66–6.60) | ||||
| Dominant | A/A | 50 (53.2%) | 32 (34%) | 1.00 (reference) | .008* | 259.4 | 269.2 |
| A/G-G/G | 44 (46.8%) | 62 (66%) | 2.19 (1.22–3.95) | ||||
| Recessive | A/A-A/G | 88 (93.6%) | 86 (91.5%) | 1.00 (reference) | .57 | 266.1 | 275.8 |
| G/G | 6 (6.4%) | 8 (8.5%) | 1.38 (0.46–4.14) | ||||
| Overdominant | A/A-G/G | 56 (59.6%) | 40 (42.5%) | 1.00 (reference) | .02* | 261 | 270.8 |
| A/G | 38 (40.4%) | 54 (57.5%) | 1.98 (1.11–3.54) | ||||
| Log-additive | — | — | — | 1.77 (1.10–2.87) | .018* | 260.8 | 270.5 |
| P4 polymorphism (rs76968380) | |||||||
| Codominant | G/G | 88 (93.6%) | 80 (85.1%) | 1.00 (reference) | .073 | 263.2 | 276.1 |
| A/G | 6 (6.4%) | 12 (12.8%) | 2.22 (0.79–6.19) | ||||
| A/A | 0 (0%) | 2 (2.1%) | NA (0.00–NA) | ||||
| Dominant | G/G | 88 (93.6%) | 80 (85.1%) | 1.00 (reference) | .054 | 262.7 | 272.4 |
| A/G-A/A | 6 (6.4%) | 14 (14.9%) | 2.58 (0.95–7.05) | ||||
| Recessive | G/G-A/G | 94 (100%) | 92 (97.9%) | 1.00 (reference) | .095 | 263.6 | 273.3 |
| A/A | 0 (0%) | 2 (2.1%) | NA (0.00–NA) | ||||
| Overdominant | G/G-A/A | 88 (93.6%) | 82 (87.2%) | 1.00 (reference) | .13 | 264.1 | 273.9 |
| A/G | 6 (6.4%) | 12 (12.8%) | 2.16 (0.77–6.03) | ||||
| Log-additive | — | — | — | 2.58 (1.01–6.60) | .033* | 261.9 | 271.6 |
| P5 polymorphism (rs34406737) | |||||||
| Codominant | G/G | 63 (67%) | 72 (76.6%) | 1.00 (reference) | .003* | 256.9 | 269.9 |
| A/G | 31 (33%) | 17 (18.1%) | 0.48 (0.24–0.95) | ||||
| A/A | 0 (0%) | 5 (5.3%) | NA (0.00–NA) | ||||
| Dominant | G/G | 63 (67%) | 72 (76.6%) | 1.00 (reference) | .15 | 264.4 | 274.1 |
| A/G-A/A | 31 (33%) | 22 (23.4%) | 0.63 (0.33–1.19) | ||||
| Recessive | G/G-A/G | 94 (100%) | 89 (94.7%) | 1.00 (reference) | .008* | 259.4 | 269.1 |
| A/A | 0 (0%) | 5 (5.3%) | NA (0.00–NA) | ||||
| Overdominant | G/G-A/A | 63 (67%) | 77 (81.9%) | 1.00 (reference) | .02* | 261 | 270.7 |
| A/G | 31 (33%) | 17 (18.1%) | 0.45 (0.23–0.89) | ||||
| Log-additive | — | — | — | 0.86 (0.49–1.49) | .58 | 266.1 | 275.8 |
| P6 polymorphism (rs1963250) | |||||||
| Codominant | T/T | 20 (21.3%) | 37 (39.4%) | 1.00 (reference) | .016* | 260.2 | 273.1 |
| T/G | 54 (57.5%) | 46 (48.9%) | 0.46 (0.24–0.91) | ||||
| G/G | 20 (21.3%) | 11 (11.7%) | 0.30 (0.12–0.75) | ||||
| Dominant | T/T | 20 (21.3%) | 37 (39.4%) | 1.00 (reference) | .007* | 259.2 | 268.9 |
| T/G-G/G | 74 (78.7%) | 57 (60.6%) | 0.42 (0.22–0.80) | ||||
| Recessive | T/T-T/G | 74 (78.7%) | 83 (88.3%) | 1.00 (reference) | .079 | 263.3 | 273.1 |
| G/G | 20 (21.3%) | 11 (11.7%) | 0.49 (0.22–1.10) | ||||
| Overdominant | T/T-G/G | 40 (42.5%) | 48 (51.1%) | 1.00 (reference) | .25 | 265.1 | 274.8 |
| T/G | 54 (57.5%) | 46 (48.9%) | 0.71 (0.40–1.27) | ||||
| Log-additive | — | — | — | 0.53 (0.34–0.83) | .005* | 258.5 | 268.2 |
| P7 polymorphism (rs10755950) | |||||||
| Codominant | G/G | 33 (35.1%) | 31 (33%) | 1.00 (reference) | .068 | 263.1 | 276 |
| A/G | 50 (53.2%) | 40 (42.5%) | 0.85 (0.44–1.61) | ||||
| A/A | 11 (11.7%) | 23 (24.5%) | 2.19 (0.91–5.27) | ||||
| Dominant | G/G | 33 (35.1%) | 31 (33%) | 1.00 (reference) | .79 | 266.4 | 276.1 |
| A/G-A/A | 61 (64.9%) | 63 (67%) | 1.08 (0.59–1.99) | ||||
| Recessive | G/G-A/G | 83 (88.3%) | 71 (75.5%) | 1.00 (reference) | .024* | 261.3 | 271 |
| A/A | 11 (11.7%) | 23 (24.5%) | 2.42 (1.10–5.33) | ||||
| Overdominant | G/G-A/A | 44 (46.8%) | 54 (57.5%) | 1.00 (reference) | .14 | 264.3 | 274 |
| A/G | 50 (53.2%) | 40 (42.5%) | 0.65 (0.36–1.15) | ||||
| Log-additive | — | — | — | 1.34 (0.89–2.03) | .16 | 264.4 | 274.2 |
| P8 polymorphism (rs56055423) | |||||||
| Codominant | A/A | 91 (96.8%) | 81 (86.2%) | 1.00 (reference) | .023* | 260.8 | 273.8 |
| A/G | 3 (3.2%) | 12 (12.8%) | 4.44 (1.20–16.44) | ||||
| G/G | 0 (0%) | 1 (1.1%) | NA (0.00-NA) | ||||
| Dominant | A/A | 91 (96.8%) | 81 (86.2%) | 1.00 (reference) | .007* | 259.3 | 269 |
| A/G-G/G | 3 (3.2%) | 13 (13.8%) | 4.83 (1.32–17.67) | ||||
| Recessive | A/A-A/G | 94 (100%) | 93 (98.9%) | 1.00 (reference) | .23 | 265 | 274.7 |
| G/G | 0 (0%) | 1 (1.1%) | NA (0.00-NA) | ||||
| Overdominant | A/A-G/G | 91 (96.8%) | 82 (87.2%) | 1.00 (reference) | .014* | 260.4 | 270.1 |
| A/G | 3 (3.2%) | 12 (12.8%) | 4.41 (1.19–16.33) | ||||
| Log-additive | — | — | — | 4.64 (1.30–16.56) | .006* | 259 | 268.7 |
Association analysis between polymorphisms and gender incongruence. The table shows the estimation of the OR (odds ratio) for each genotype with respect to the reference genotype (1.00 (reference)) in different inheritance models (codominant, dominant, recessive, overdominant and log-additive. AIC = Akaike's information criterion; BIC = Bayesian information criterion; OR = odds ratio.
⁎
Statistically significant (P < .05).