. 2021 Jun 29;22:599. doi: 10.1186/s12891-021-04472-6

Table 4.

Relationship between methylation rates and steroid-related osteonecrosis of femoral head

Gene_ID	Group	Number of subjects		p value ^a
Gene_ID	Group	Non-Meth.	Meth.	p value ^a
OPG2_CpG_1	Control	27	23	0.001
OPG2_CpG_1	Case	10	39	0.001
OPG2_CpG_5	Control	30	17	0.039
OPG2_CpG_5	Case	20	27	0.039
OPG2_CpG_10.11	Control	42	6	0.007
OPG2_CpG_10.11	Case	32	18	0.007
RANK1_CpG_2	Control	17	32	0.008
RANK1_CpG_2	Case	6	44	0.008
RANK1_CpG_6	Control	18	30	0.004
RANK1_CpG_6	Case	6	43	0.004
RANK1_CpG_18	Control	16	33	0.028
RANK1_CpG_18	Case	7	43	0.028
RANK1_CpG_20	Control	34	15	0.001
RANK1_CpG_20	Case	18	32	0.001
RANK1_CpG_24.25.26.27	Control	16	32	0.013
RANK1_CpG_24.25.26.27	Case	6	43	0.013
RANK2_CpG_10.11	Control	19	27	0.012
RANK2_CpG_10.11	Case	9	41	0.012
RANK2_CpG_15	Control	33	14	0.003
RANK2_CpG_15	Case	20	30	0.003
RANK2_CpG_23.24.25.26.27	Control	33	14	0.005
RANK2_CpG_23.24.25.26.27	Case	21	29	0.005
RANK2_CpG_36	Control	40	7	0.048
RANK2_CpG_36	Case	34	16	0.048
RANK3_CpG_8	Control	25	21	< 0.001
RANK3_CpG_8	Case	10	40	< 0.001
RANKL1_CpG_14.15	Control	16	28	0.044
RANKL1_CpG_14.15	Case	9	41	0.044
RANKL1_CpG_19	Control	23	20	0.015
RANKL1_CpG_19	Case	14	35	0.015
RANKL1_CpG_21	Control	34	10	0.018
RANKL1_CpG_21	Case	27	23	0.018
RANKL1_CpG_24	Control	26	20	0.027
RANKL1_CpG_24	Case	17	33	0.027
RANKL2_CpG_2	Control	18	30	0.003
RANKL2_CpG_2	Case	6	44	0.003
RANKL2_CpG_9.10.11.12	Control	29	19	< 0.001
RANKL2_CpG_9.10.11.12	Case	9	41	< 0.001

Non-Meth Non-Methylation; Meth Methylation

p < 0.05 indicates statistical significance

^a chi-square test