Table 5.
Relationship between methylation and steroid-associated osteonecrosis of femoral head
| Gene_ID | OR | 95% CI | p value | |
|---|---|---|---|---|
| lower limit | upper limit | |||
| OPG2_CpG_1 | 4.62 | 1.95 | 10.95 | 0.001 |
| OPG2_CpG_5 | 3.45 | 1.32 | 9.02 | 0.005 |
| RANK1_CpG_6 | 4.83 | 1.64 | 14.25 | 0.004 |
| RANK1_CpG_15 | 4.67 | 1.82 | 12.01 | 0.001 |
| RANK1_CpG_20 | 4.25 | 1.80 | 10.05 | 0.001 |
| RANK2_CpG_10.11 | 4.76 | 1.95 | 11.65 | 0.001 |
| RANK2_CpG_15 | 4.17 | 1.69 | 10.29 | 0.002 |
| RANK2_CpG_16 | 3.71 | 1.30 | 10.59 | 0.014 |
| RANK2_CpG_21.22 | 2.90 | 1.19 | 7.05 | 0.019 |
| RANK2_CpG_23.24.25.26.27 | 3.43 | 1.45 | 8.10 | 0.005 |
| RANK2_CpG_29 | 3.48 | 1.36 | 8.91 | 0.009 |
| RANK2_CpG_36 | 2.95 | 1.27 | 6.86 | 0.012 |
| RANK3_CpG_8 | 6.56 | 2.54 | 16.93 | < 0.001 |
| RANK3_CpG_10 | 3.91 | 1.65 | 9.27 | 0.002 |
| RANKL1_CpG_1 | 12.66 | 4.10 | 39.11 | < 0.001 |
| RANKL1_CpG_12.13 | 3.57 | 1.42 | 8.98 | 0.007 |
| RANKL1_CpG_14.15 | 3.10 | 1.30 | 7.38 | 0.011 |
| RANKL1_CpG_19 | 6.92 | 2.66 | 18.00 | < 0.001 |
| RANKL1_CpG_21 | 3.05 | 1.30 | 7.12 | 0.010 |
| RANKL1_CpG_24 | 2.44 | 1.05 | 5.64 | 0.038 |
| RANKL1_CpG_25.26.27 | 5.89 | 2.32 | 14.93 | < 0.001 |
| RANKL1_CpG_44.45 | 3.84 | 1.53 | 9.62 | 0.004 |
| RANKL1_CpG_46 | 3.74 | 1.40 | 9.97 | 0.008 |
| RANKL2_CpG_9.10.11.12 | 3.18 | 1.31 | 7.73 | 0.011 |
OR odds ratio; CI confidence interval
p < 0.05 indicates statistical significance
p values were calculated by logistic regression adjusted for age and sex