Table 5.
Multivariable logistic regression analysis on risk factors for pregnancy outcomes in short-acting GnRH-a long protocol (n = 1000)
| Potential risk factor variables | Adjusted OR* (95% CI) | P-value |
|---|---|---|
| Clinical pregnancy | ||
| FET timing (Immediate FETa versus delayed FETb) | 0.985 (0.751–1.294) | NS |
| Age (35–37 versus ≤34) | 0.987 (0.636–1.530) | NS |
| Age (≥38 versus ≤34) | 0.414 (0.194–0.879) | P < 0.05 |
| BMI (< 18.5 versus 18.5–24.9) | 1.391 (0.792–2.442) | NS |
| BMI (≥25 versus 18.5–24.9) | 1.278 (0.918–1.778) | NS |
| Insemination method (ICSI versus IVF) | 0.727 (0.508–1.040) | NS |
| Number of embryo transferred (2 versus 1) | 1.401 (0.911–2.155) | NS |
| Embryo stage (blastocyst versus cleavage) | 2.318 (1.595–3.370) | P < 0.001 |
| Top or good quality embryo transfer (yes versus no) | 1.148 (0.824–1.598) | NS |
| Tubal factor (yes versus no) | 1.109 (0.767–1.603) | NS |
| Ovulatory disorder (yes versus no) | 0.934 (0.634–1.375) | NS |
| Male factor (yes versus no) | 1.229 (0.849–1.780) | NS |
| Unexplained factor (yes versus no) | 2.101 (0.888–4.971) | NS |
| Spontaneous abortion | ||
| FET timing (Immediate FETa versus delayed FETb) | 1.311 (0.826–2.080) | NS |
| Age (35–37 versus ≤34) | 1.202 (0.604–2.392) | NS |
| Age (≥38 versus ≤34) | 1.047 (0.297–3.699) | NS |
| BMI (< 18.5 versus 18.5–24.9) | 1.246 (0.506–3.067) | NS |
| BMI (≥25 versus 18.5–24.9) | 2.693 (1.681–4.314) | P < 0.001 |
| Insemination method (ICSI versus IVF) | 1.069 (0.567–2.015) | NS |
| Number of embryo transferred (2 versus 1) | 0.856 (0.433–1.693) | NS |
| Embryo stage (blastocyst versus cleavage) | 0.853 (0.470–1.547) | NS |
| Top or good quality embryo transfer (yes versus no) | 1.380 (0.764–2.495) | NS |
| Tubal factor (yes versus no) | 0.439 (0.229–0.841) | P < 0.05 |
| Ovulatory disorder (yes versus no) | 0.863 (0.459–1.621) | NS |
| Male factor (yes versus no) | 0.349 (0.173–0.706) | P < 0.01 |
| Unexplained factor (yes versus no) | 0.225 (0.046–1.102) | NS |
| Live birth | ||
| FET timing (Immediate FETa versus delayed FETb) | 0.929 (0.714–1.209) | NS |
| Age (35–37 versus ≤34) | 0.968 (0.634–1.478) | NS |
| Age (≥38 versus ≤34) | 0.430 (0.195–0.949) | P < 0.05 |
| BMI (< 18.5 versus 18.5–24.9) | 1.263 (0.743–2.150) | NS |
| BMI (≥25 versus 18.5–24.9) | 0.856 (0.625–1.173) | NS |
| Insemination method (ICSI versus IVF) | 0.797 (0.562–1.130) | NS |
| Number of embryo transferred (2 versus 1) | 1.362 (0.913–2.033) | NS |
| Embryo stage (blastocyst versus cleavage) | 2.283 (1.613–3.231) | P < 0.001 |
| Top or good quality embryo transfer (yes versus no) | 1.134 (0.820–1.569) | NS |
| Tubal factor (yes versus no) | 1.458 (1.017–2.091) | P < 0.05 |
| Ovulatory disorder (yes versus no) | 0.920 (0.631–1.341) | NS |
| Male factor (yes versus no) | 1.581 (1.105–2.262) | P < 0.05 |
| Unexplained factor (yes versus no) | 2.914 (1.306–6.500) | P < 0.01 |
Abbreviations: BMI, body mass index; FET, frozen embryo transfer; GnRH-a, gonadotrophin-releasing hormone agonist; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; OR, odds ratio; CI, confidence interval; NS, not significant
aImmediate FET and bdelayed FET means FET took place either within the first menstrual cycle following oocyte retrieval or afterwards
*Using the multivariable logistic regression and adjusting for maternal age, BMI, insemination method, number of embryo transferred, embryo stage, top or good quality embryo transfer, and cause of infertility