Table 6.
Multivariable logistic regression analysis on risk factors for pregnancy outcomes in long-acting GnRH-a long protocol
| Potential risk factor variables | Adjusted OR* (95% CI) | P-value |
|---|---|---|
| Clinical pregnancy | ||
| FET timing (Immediate FETa versus delayed FETb) | 0.607 (0.322–1.147) | NS |
| Age (35–37 versus ≤34) | 1.218 (0.471–3.150) | NS |
| Age (≥38 versus ≤34) | 0.810 (0.1052–6.257) | NS |
| BMI (< 18.5 versus 18.5–24.9) | 0.980 (0.293–3.277) | NS |
| BMI (≥25 versus 18.5–24.9) | 1.525 (0.715–3.256) | NS |
| Insemination method (ICSI versus IVF) | 1.151 (0.463–2.862) | NS |
| Top or good quality embryo transfer (yes versus no) | 8.805 (2.515–30.827) | P < 0.01 |
| Embryo stage (blastocyst versus cleavage) | 1.425 (1.163–5.056) | P < 0.05 |
| Tubal factor (yes versus no) | 2.454 (0.924–6.518) | NS |
| Ovulatory disorder (yes versus no) | 0.840 (0.229–3.085) | NS |
| Male factor (yes versus no) | 2.844 (1.147–7.051) | P < 0.05 |
| Unexplained factor (yes versus no) | 1.335 (0.204–8.721) | NS |
| Spontaneous abortion | Adjusted OR# (95% CI) | |
| FET timing (Immediate FETa versus delayed FETb) | 0.380 (0.143–1.010) | NS |
| Age (35–37 versus ≤34) | 0.409 (0.088–1.878) | NS |
| Age (≥38 versus ≤34) | – | NS |
| BMI (< 18.5 versus 18.5–24.9) | 0.544 (0.066–4.491) | NS |
| BMI (≥25 versus 18.5–24.9) | 1.914 (0.759–4.827) | NS |
| Top or good quality embryo transfer (yes versus no) | 0.836 (0.207–3.375) | NS |
| Live birth | Adjusted OR* (95% CI) | P-value |
| FET timing (Immediate FETa versus delayed FETb) | 0.995 (0.543–1.823) | NS |
| Age (35–37 versus ≤34) | 2.034 (0.800–5.168) | NS |
| Age (≥38 versus ≤34) | 1.991 (0.248–15.991) | NS |
| BMI (< 18.5 versus 18.5–24.9) | 1.290 (0.396–4.195) | NS |
| BMI (≥25 versus 18.5–24.9) | 1.034(0.507–2.111) | NS |
| Insemination method (ICSI versus IVF) | 1.422 (0.607–3.334) | NS |
| Top or good quality embryo transfer (yes versus no) | 13.211 (2.621–66.596) | P < 0.01 |
| Embryo stage (blastocyst versus cleavage) | 2.339 (1.186–4.614) | P < 0.05 |
| Tubal factor (yes versus no) | 2.025 (0.842–4.868) | NS |
| Ovulatory disorder (yes versus no) | 0.552 (0.148–2.057) | NS |
| Male factor (yes versus no) | 1.470 (0.658–3.286) | NS |
| Unexplained factor (yes versus no) | 0.397 (0.054–2.935) | NS |
Abbreviations: BMI, body mass index; FET, frozen embryo transfer; GnRH-a, gonadotrophin-releasing hormone agonist; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; OR, odds ratio; CI, confidence interval; NS, not significant
aImmediate FET and bdelayed FET means FET took place either within the first menstrual cycle following oocyte retrieval or afterwards
*Using the multivariable logistic regression and adjusting for maternal age, BMI, insemination method, trigger type, embryo stage, top or good quality embryo transfer, and cause of infertility
# Using the multivariable logistic regression and adjusting for maternal age, BMI, top or good quality embryo transfer
“-” means that the number of miscarriages in the group over 38 years old is 0.