Fig. 3.

hPMSCs improve redox metabolism and alleviate GVHD symptoms. The level of MDA (a) and the activity of SOD (b) in GVHD patients and healthy donors (n = 7). The levels of carbonyl, T-GSH, GSH, and GSSG; the ratio of GSH/GSSG; and the activities of SOD and GCL in the spleen (c) and liver (d) of GVHD mice in different groups (n = 5). e Representative histological changes observed in the liver and skin samples harvested from different groups of GVHD mice. Scale bar = 60 μm. Masson’s trichrome and PAS staining analysis of the changes in the liver in different groups of GVHD mice, respectively. Red arrows indicate the infiltration of inflammatory cells, black arrows indicate the liver glycogen, and blue arrows indicate the collagen fibers. f Weight changes and disease scores and the activities of ALT and AST, in the different groups of GVHD mice (n = 5). The results were obtained from three independent experiments, *P < 0.05, **P < 0.01