| Domain | Judgement | Support for judgement |
| Random sequence generation (selection bias) | ||
| Allocation concealment (selection bias) | ||
| Blinding of participants and personnel (performance bias) | ||
| Blinding of outcome assessment (detection bias) | ||
| Incomplete outcome data (attrition bias) | ||
| Selective reporting of benefit outcomes based on ORBIT‐1 (reporting bias) | ||
| Selective reporting of harm outcomes on ORBIT‐2 | ||
| Other bias |
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