Table 1.

Biological characteristics of three genotypes of mice at 7 months old

Characteristics	Lias+/+Leprdb/+	Lias+/+Leprdb/db	LiasH/HLeprdb/db	P1	P2
Body weight (g)	31.54±1.05	65.56±2.03	74.27±1.71	0.001	0.001
Right kidney weight (mg)	244.26±8.04	242.58±7.61	248.85±13.90	0.909	0.669
Chow intakes (g/day）	10.11±0.09	16.03±0.72	13.98±0.18	0.001	0.093
Water intakes (mL/day）	14.60±0.84	13.33±0.05	11.15±0.11	0.035	0.001
Urine output (mL/day）	2.21±0.12	16.94±0.51	13.44±0.65	0.001	0.001
TG (mM)	0.75±0.030	1.35±0.10	1.16±0.11	0.001	0.542
CHO (mM)	2.37±0.21	6.06±0.62	9.35±0.77	0.001	0.015

All mice were male at 7 months of age. Data are represented as mean±SEM (n=10). P₁ represents p value of Lias^+/+Leprdb^db/db vs Lias^+/+/Leprdb^/+ mice and P₂ stands for p value of Lias^H/HLepr^db/db vs Lias^+/+Leprdb^db/db mice.

CHO, cholesterol; TG, triglyceride.