Table 3.
Definitions | Thyroid hormone patterns | ICU (n = 80) | Ward (n = 101) | Outpatients (n = 15) | ||
---|---|---|---|---|---|---|
COVID-19 (n = 41) | Non-COVID-19 (n = 39) | COVID-19 (n = 46) | Non-COVID-19 (n = 55) | COVID-19 (n = 15) | ||
Normal (41.3%) | 12 (29.3%) | 9 (23.1%) | 25 (54.3%) | 25 (45.5%) | 10 (66.7%) | |
Non-thyroidal illness syndrome (43.4%) | 23 (56.1%) | 26 (66.7%) | 18 (39.1%) | 21 (38.2%) | 3 (20%) | |
Only Low T3 (34.2%) | 18 (43.9%) | 16 (41.0%) | 16 (34.8%) | 17 (30.9%) | 0 | |
Low T3 and low FT4 and normal TSH (4.1%) | 3 (7.3%) | 4 (10.3%) | 0 | 1 (1.8%) | 0 | |
Low T3, low/low-normal FT4 and low TSH (5.1%) | 2 (4.9%) | 5 (12.8%) | 1 (2.2%) | 1 (1.8%) | 1 (6.7%) | |
High FT4, low/normal T3 and normal TSH (4.6%) | 0 | 1 (2.6%) | 1 (2.2%) | 2 (3.6%) | 2 (13.3%) | |
Thyrotoxicosis (8.2%) | 6 (14.6%) | 3 (7.7%) | 2 (4.3%) | 4 (7.3%) | 1 (6.7%) | |
Overt thyrotoxicosis (1.5%) | High FT4 and/or high T3 and low TSH | 1 (2.4%) | 0 | 1 (2.2%) | 1 (1.8%) | 0 |
Subclinical thyrotoxicosis (6.6%) | High-normal FT4 and low TSH | 5 (12.5%) | 3 (7.7%) | 1 (2.2%) | 3 (5.5%) | 1 (6.7%) |
Hypothyroidism (4.1%) | ||||||
Overt hypothyroidism (0.5%) | High TSH and low FT4 | 0 | 0 | 0 | 1 (1.8%) | 0 |
Subclinical hypothyroidism (3.6%) | High TSH and normal FT4 | 0 | 1 (2.6%) | 1 (2.2%) | 4 (7.3%) | 1 (6.7%) |
Normal ranges; FT4 0.9–1.7 ng/dL (low < 0.9 ng/dL, low-normal <1.3 ng/dL, high-normal>1.3 ng/dL, high > 1.7 ng/dL), T3 80–200 ng/dL (low < 80 ng/dL, high > 200 ng/dL), TSH 0.3–4.2 μIU/mL (low<0.3 μIU/mL, high> 4.2 μIU/mL).