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. 2021 Mar 18;144(4):1247–1262. doi: 10.1093/brain/awab013

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tracts with reduced fractional anisotropy associated with apathy. Relevant brain regions are highlighted to demonstrate tract positions relative to the dorsal ACC (dACC, blue), vMPFC, and the nucleus accumbens (nAcc), all implicated in effort based decision-making studies in healthy individuals. Note no regions were identified to be associated with depression (bottom). AC = anterior cingulum; ALIC = anterior limb of the internal capsule; ATR = anterior thalamic radiation; EC = external capsule; IFOF = inferior fronto-occipital fasciculus; UF = uncinate fasciculus.