TABLE 3.

Breakpoint structure characteristics and potential mechanisms.

Breakpoint structure characteristic	Number	Percentage (%)	Potential mechanism
No additional sequence at breakpoint
0 or 1 matching nucleotides	8	36.4%	NHEJ
2–20 matching nucleotides	13	59.1%	MMEJ
>20 matching nucleotides	0	0.0%
Additional sequence at breakpoint
1–10 additional nucleotides	1	4.5%	AROR
>10 additional nucleotides	0	0.0%

NAHR, non-allelic homologous recombination; NHEJ, non-homologous end-joining; MMEJ, microhomology-mediated end-joining; AROR, aberrant replication origin firing.