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. 2021 Jun 11;12:670727. doi: 10.3389/fgene.2021.670727

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Copyright © 2021 Piras, Breno, Valoti, Alberti, Iatropoulos, Mele, Bresin, Donadelli, Cuccarolo, Smith, Benigni, Remuzzi and Noris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphic representation of MLPA results from the patient carrying the CFH-CFHR3-CFHR1 deletion and patients with CFHR4 duplication. (A) MLPA results showing the genomic deletion, including the entire copy of CFH, CFHR3, and CFHR1 in a patient with IC-MPGN (#2888; cluster 2). (B) Analysis of MLPA showing three copies of CFHR1 and CFHR4 in two C3GN patients (#2856 and #2979; both from cluster 1) and one copy of CFHR3, two copies of CFHR1 and 3 copies of CFHR4 in two patients with IC-MPGN and DDD (#1726 cluster 2; #1549, cluster 3), respectively.