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Blood concentration versus time profile following oral administration of uncoated or 1, 2 or 5 kDa PEG-coated 5 nm AuNPs. Rats were administered a single oral dose (8.0 mg/kg) of 1, 2 or 5 kDa PEG coated 5 nm AuNPs by gavage. Blood samples were taken over time for up to 48 hours and AuNP concentrations in blood were measured. Results are plotted beginning with 0 h (just prior to the dose) and are expressed as mean ± SD (N = 5).
